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Epithelial supporting cells can differentiate into outer hair cells and Deiters' cells in the cultured organ of Corti 总被引:2,自引:0,他引:2
Malgrange B Thiry M Van De Water TR Nguyen L Moonen G Lefebvre PP 《Cellular and molecular life sciences : CMLS》2002,59(10):1744-1757
The organ of Corti is a complex structure containing a single row of inner hair cells (IHCs) and three rows of outer hair
cells (OHCs), supported respectively by one row of inner phalangeal cells and three rows of Deiters' cells. When fetal rat
organ of Corti explants are cultured, supernumerary OHCs and supernumerary Deiters' cells are produced, without any additional
cell proliferation. Analysis of semi- and ultrathin sections revealed that supernumerary OHCs are produced at the distal edge
of the organ of Corti. Quantitative analysis of cell types present in the organ of Corti demonstrates that when the number
of OHCs increases: (i) the total number of cells remains constant; (ii) the number of Deiters' cells increases; (iii) the
number of tectal cells decreases and of Hensen's cells decreases. Using specific HC markers, i.e. jagged2 (Jag2) and Math1,
we showed that in addition to existing OHCs, supernumerary OHCs, tectal cells and Hensen's cells expressed these markers in
embryonic day 19 organ of Corti explants after 5 days in vitro. The results of this study suggest that Hensen's cells retain
the capacity to differentiate into either tectal cells, which differentiate into OHCs, or into undertectal cells which differentiate
into Deiters' cells.
Received 15 May 2002; received after revision 18 July 2002; accepted 7 August 2002
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根据蟾蜍视顶盖神经元感受野的大小和构型识别的特点进行分类。用方波翻转栅条对蟾蜍视顶盖神经元的空间频率特性进行研究。并对空间频率特性与蟾蜍行为之间的关系和生物学的意义做了初步探讨。 相似文献
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