南海红树内生真菌2534号的鞘脂类代谢产物

内生真菌2534号分离自南海红树Avicennia marina的种子,从其菌丝体分离到3个化合物(A-C),它们的结构通过分析波谱数据分别鉴定为N-二十六碳酰基-2-氨基-1,3-二羟基十八烷(A)、N-(2-羟基二十碳酰基)-2-氨基-1,3,4-三羟基十八烷(B)和N-二十一碳酰基-2-氨基-1-O-吡喃葡萄糖基-3,4-二羟基十八烷(C)。     

猪脑组织中磷脂的综合提取研究

介绍了利用哺乳动物猪脑组织提取神经醇磷酸，卵磷脂和脑磷脂的工艺流程，并对某些关键环节进行了分析讨论，不仅为研究磷脂的生物学效应提供了原料，也为猪脑组织的综合利用开辟了一条可行的途径。     

鞘脂合成的中间代谢酶类的研究进展

鞘脂类是真核细胞膜上普遍存在的组份，它在真核细胞的胞吞、胞饮、信号转导、细胞的生长、凋亡、分化、衰老等过程中起着非常重要的作用。本文介绍了近年来鞘脂类代谢过程中的主要酶的结构与功能以及鞘脂在真核细胞中的转运机制。     

神经醇磷脂的生物学功能和细胞病理

神经醇磷脂广泛存在于所有真核生物细胞中，包括神经鞘髓磷脂、酰基鞘氨醇，脑苷类和神节甙脂类，神经醇磷脂参与重要的细胞生理活动，神经元的生长，细胞的能 性，细胞的调控等都与神经醇磷脂有关；另外，神经醇磷脂的异常还会导致一些疾病，如高歇氏病，疟疾，细胞的恶性生长等。     

Separation and Detection of Ceramides by HPLC Followed by Evaporative Light-Scattering Detection and Thin Layer Chromatography

IntroductionCeramides,simple sphingolipids,exist ineukaryotic cells either as free molecules or as thebackbone of all sphingolipid molecules. Asstructural components they are mostly localized inthe plasma membrane,contributing to membraneproperties such as increased rigidity and thestability of the lipid bilayer[1] .Their hydrophobicnature provides a hydrophobic environment for theoptimal activity of membrane- related enzymes andproteins. These molecules are redistributed acrossthe membrane bi…     

The GPI-anchor and protein sorting

Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are a diverse class of proteins that are anchored to the membrane solely via means of a posttranslational lipid modification, the GPI-moiety. Since their discovery in the late 1970s, years of research have provided significant insight into the functions of this ubiquitous modification. In addition to the structure and biosynthesis of the GPI-moiety, perhaps the best-studied feature of this glycolipid is its ability to impart characteristic membrane-trafficking properties to the proteins that it anchors. Study of the mechanism of sorting of GPI-APs has brought to light the importance of lateral heterogeneities in cell membranes, termed rafts, in biological sorting processes. The focus of this review is to examine the emerging role of the GPI-anchor and mechanisms involved in GPI-AP sorting in the context of intracellular trafficking pathways.