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Patrick H. Toy Helen Song He Cathy Kar-Wing Kwong 《复旦学报(自然科学版)》2005,44(5):833-834
1 Introduction Recent years have seen a growing use of polymer-supported reagents by organic chemists in traditional solution-phase synthesis.Of the many reagents supported by polymers available, variations of triphenylphosphine are among the most broadly used. This is because triphenylphosphine is not only a reagent in a wide range of organic reactions~([1]), but it also serves as a ligand in many organometallic reagents~([2]).Most importantly, polymer-supported triphenylphosphine affords the… 相似文献
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The catalytic potential of carbon nucleophiles has seldom been disclosed due to their reactivity toward carbon electrophiles to form stable carbon-carbon bonds, which are too strong to be cleaved for the expected catalytic cycles. We have developed an efficient catalytic cyanosilylation of carbonyl compounds with an in situ generated alkene/phosphine adduct, which is tuned not to couple with a carbonyl compound or an electron-deficient alkene under the reaction conditions when its nucleophilicity is translated into catalytic activity. In the presence of 3 mol% of methyl acrylate and 3 mol% of triphenylphosphine, a broad range of alkyl, alkenyl, and aryl ketones and aldehydes undergo cyanosilylation reaction with trimethylsilyl cyanide at room temperature to yield structurally diversified cyanohydrin silyl ethers in excellent yields. By using methyl acrylate/triphenylphosphine as a highly effective nucleophilic catalyst system for the cyanosilylation of carbonyl compounds, this study demonstrates a new concept for the development of useful organocatalysis utilizing the nucleophilicity of alkene/phosphine adducts generated in situ. 相似文献
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4-二苯膦代苯并-18-冠-6是水两相催化体系中的一种新型水溶性膦配体.文章以Benzo-18-Crown-6为原料,经碘代及二苯膦取代等3步反应合成这一膦配体,结果满意. 相似文献
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In the past decade, the asymmetric Morita-Baylis-Hillman (MBH)/aza-Morita-Baylis-Hillman (aza-MBH) reaction has attracted great attention because it leads to the formation of densely functionalized products in a catalytic and atom-economic way. The MBH/aza-MBH adducts can be further applied in a wide variety of organic synthesis, such as peptide synthesis and heterocyclic compounds synthesis. After a lot of attempts to improve the enantioselectivity, many types of chiral organocatalysts have been identified as highly enantioselective organocatalysts in MBH/aza-MBH reaction. Especially, certain “privileged chiral catalysts” are highly enantioselective in MBH/aza-MBH reaction, which are designed and developed through introducing bi-/multi-functional groups on the so-called “privileged structures” such as cinchona alkaloids, BINAP/BINOL. This review summarizes the exciting advances about the design and development of chiral catalysts derived from “privileged structures” and their applications in asymmetric MBH/aza-MBH reaction. 相似文献
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