彩色多普勒超声在诊断心肌致密化不全中的应用

目的：探讨超声心动图对心肌致密化不全的诊断价值。方法：重点观察心室近心尖1/3的心肌与心内膜。彩色多普勒血流检测时降低量程，以便更好显示隐窝间隙的低速血流。结果：所有28例患者超声心动图检查均可见心腔内异常突起、粗大的肌小梁和其间的隐窝影像，24例为左室型，4例双室型。26例伴有充血性心力衰竭症状。4例左室内血栓形成。结论：超声心动图是诊断该病的重要手段，具有特征性意义。     

Functions of fatty acid binding proteins

Summary Cytosolic fatty acid binding proteins (FABP) belong to a gene family of which eight members have been conclusively identified. These 14–15 kDa proteins are abundantly expressed in a highly tissue-specific manner. Although the functions of the cytosolic FABP are not clearly established, they appear to enhance the transfer of long-chain fatty acids between artificial and native lipid membranes, and also to have a stimulatory effect on a number of enzymes of fatty acid metabolism in vitro. These findings, as well as the tissue expression, ligand binding properties, ontogeny and regulation of these proteins provide a considerable body of indirect evidence supporting a broad role for the FABP in the intracellular transport and metabolism of long-chain fatty acids. The available data also support the existence of structure- and tissue-specific specialization of function among different members of the FABP gene family. Moreover, FABP may also have a possible role in the modulation of cell growth and proliferation, possibly by virtue of their affinity for ligands such as prostaglandins, leukotrienes and fatty acids, which are known to influence cell growth activity. FABP structurally unrelated to the cytosolic gene family have also been identified in the plasma membranes of several tissues (FABP_pm). These proteins have not been fully characterized to date, but strong evidence suggests that they function in the transport of long-chain fatty acids across the plasma membrane.     

Molecular mechanism for the production of multiple form of MM creatine kinase

Summary Incubation of human, canine or rabbit MM creatine kinase with carboxypeptidase-N or B resulted in the production of 2 additional enzyme forms with increased anodal migration on polyacrylamide gels. The C-terminal amino acid of tissue MM creatine kinase from all 3 species was shown to be lysine, a specific substrate for carboxypeptidase-N and B.     

Identification of a pre-hibernating state in myocardium from nonhibernating chipmunks

Summary During the hibermating season, the amplitude of the cardiac action potential plateau of nonhibernating chipmunks was reduced. Replacing external Ca by Sr inhibited the electromechanical responses of these preparations. Similar properties were observed in hibernating animal preparations, suggesting that changes in cardiac function are already triggered before hibernation begins.15 December 1986     

葡萄糖转运体4与Ⅱ型糖尿病相互关系的研究进展

葡萄糖转运体4(GLUT4)是转运葡萄糖的重要蛋白质,与Ⅱ型糖尿病(T2DM)密切相关.从GLUT4对骨骼肌、心肌和脂肪组织,以及肾组织的肾小球系膜细胞的影响等方面进行了综述,研究葡萄糖转运体4与Ⅱ型糖尿病相互关系.     

槭酮对抗大鼠急性心肌缺血和血栓形成的研究

目的 观察槭酮(槭叶草总黄酮)对垂体后叶素引起大鼠心电图S-T段变化的影响以及观察槭酮对血小板血栓形成的影响.方法 灌胃给药法.结果 中剂量和大剂量组具有一定对抗垂体后叶素引起的S-T段变化的作用,槭酮大剂量组具有较好的抗血小板血栓作用.结论 槭酮对大鼠缺血性心肌具有保护作用并可对抗血小板血栓的形成,具有一定抗血小板聚集作用.     

油橄榄叶提取物对铅中毒小鼠心肌乳酸脱氢酶活性和抗氧化能力的影响

目的:探讨油橄榄叶提取物(OLE)对铅中毒小鼠心肌乳酸脱氢酶活性和抗氧化能力的影响.方法:选健康小鼠,每日灌胃醋酸铅溶液的同时灌胃不同剂量的OLE进行治疗,连续用药30 d,检测心肌乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)、谷胱苷肽过氧化物酶(GSH-PX)活性和丙二醛(MDA)含量.结果:与模型对照组相比,小鼠灌胃OLE后心肌SOD和GSH-PX活性升高,LDH活性和MDA含量降低.结论:OLE对铅中毒小鼠有一定的疗效,能影响心肌ATP酶活性和抗氧化能力,阻止铅对心肌的毒性.     

激光心肌血管重建术的蒙特卡罗模拟研究

利用蒙特卡罗方法对激光心肌血管重建术进行了研究,研究结果表明:心肌组织对激光光子的吸收越强、散射越弱,则激光对心肌组织造成的热损伤就越小,打孔的精确度也越高,孔道灌注缺血心肌组织的能力越强;并且吸收系数的影响最大,散射的各向异性系数的影响最小;因此,能被心肌组织强吸收的激光是心肌血管重建术的理想选择。     

Myocardial dystrophin immunolocalization at sarcolemma and transverse tubules

Using monoclonal antibodies against two different regions of the helical rod part of dystrophin¹, we have localized dystrophin on both plasma membrane and transverse tubules in cardiac muscle of man and several animal species. The staining persisted after experimental ischaemia, and was observed in long-standing heart disease. No immunostaining was seen at the intercalated discs. In skeletal muscle the same two antibodies stained only the plasma membrane.     

Difference of the inhibitory action of verapamil on the positive inotropic effect of Ca2+ between spontaneously hypertensive and normotensive rat myocardium

Summary Verapamil, a calcium entry blocker, had a greater inhibitory effect on the positive inotropic effect of excess Ca²⁺ in SHR than in NWR, suggesting that the cardiac responsiveness to verapamil was enhanced in SHR.