酚类疏水性参数与有机性无机性比值的相关性研究

基于有机概念图，探索酚类化合物的有机性无机性比值OI与其正辛醇／水分配系数logKow之间的相关性，结果令人满意。     

有机结构中有机性无机性比值OI的研究

基于有机概念图，探索脂肪醛酮化合物的有机性无机性比值OI与其沸点bp之间的相关性，结果令人满意．     

亲油性纳米四氧化三铁的制备与性质

通过化学共沉淀法,在得到亲水磁性纳米四氧化三铁(Fe3O4)后,加入油酸对其进行改性,最后得到亲油性的纳米四氧化三铁颗粒.并通过透射电子显微镜(TEM),接触角仪,振动磁强计等对样品颗粒大小、磁性以及亲油性进行了分析.结果表明,该磁性颗粒样品具有超顺磁性和亲油性,能很好的分散在有机溶剂中形成磁流体.     

塔里木盆地煤层坍塌机理研究

利用化学分析和力学研究 ,探讨了塔里木盆地依奇克里克区块侏罗系和三叠系煤层的坍塌机理。这两种煤样的煤化程度较低 ,密度、强度低。煤样比表面积大 ,并含有较多亲水基团 ,相对吸水量和比吸水量都很高。由于水削弱了煤中大分子之间的氢键和范德华力 ,因而煤岩膨胀 ,致使煤岩抗压强度和抗拉强度降低 ,这是煤层坍塌的重要因素。此外 ,煤本身为有机质 ,有较强的亲油性 ,煤岩吸油后造成大分子间交联键和有机小分子的溶解 ,破坏了煤的骨架结构 ,使其强度下降     

Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques

This review begins with a general presentation of the new paradigm of drug discovery, with its emphasis on the rapid identification and elimination of compounds with unsuitable physicochemical and pharmacokinetic properties. The focus of the paper is on the various experimental methods used to determine such key physicochemical properties as ionization, lipophilicity and distribution in isotropic and anisotropic systems, solubility, and permeability across artificial membranes. Both traditional and high-throughput methods are presented and their limits highlighted. The text concludes with the trade-off between quantity/speed in high-throughput screening techniques versus greater data quality in the more labor-intensive methods. Received 23 April 2002; received after revision 25 June 2002; accepted 11 July 2002 RID="*" ID="*"Corresponding author.