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排序方式: 共有410条查询结果,搜索用时 15 毫秒
1.
D. Migliore-Samour M. Delaforge M. Jaouen D. Mansuy P. Jollès 《Cellular and molecular life sciences : CMLS》1989,45(9):882-886
Summary Immunomodulating lipopeptides lauroyl-L-Ala--D-Glu-LL-A2pmNH2-Gly (RP 44.102) and lauroyl-L-Ala--D-Glu-LL-A2pmNH2 (RP 56.142) were found to protect mice against the hepatotoxicity of paracetamol, which is due to cytochrome P-450 dependent formation of toxic metabolites and radicals. In fact they decreased the amount of hepatic microsomal cytochrome P-450, and the level of CCl4-induced lipid peroxidation. In contrast lauroyl-L-Ala--D-Glu-DD-A2pmNH2 (RP 53.204), which only differs by the configuration of the two chiral carbons of A2pm (diaminopimelic acid) and is not an immunomodulating agent, failed to protect against poisoning by paracetamol and had no effect on the level of hepatic cytochrome P-450 or the microsomal CCl4-induced lipid peroxidation. This provides a clear connection between the immunostimulating properties of a compound and its effects on xenobiotic biotransformations. 相似文献
2.
E. Umapathy 《Cellular and molecular life sciences : CMLS》1984,40(12):1431-1433
Summary Administration of estradiol-17 elicited differential responses on accessory sex glands of rats. In caput epididymis, the estrogen treatment led to an accumulation of glycerides and phospholipids while in cauda epididymis, there was no significant change. However, in seminal vesicles, depletion of phospholipids was observed In prostate, the treatment, resulted in an accumulation of glycerides.Part of Ph.D. Thesis. Umapathy, E., Thesis. University of Madras, India, 1977. 相似文献
3.
等张运动与等长运动对高血压患者的心血管反应及脂蛋白代谢的影响 总被引:1,自引:0,他引:1
目的:比较等张运动与等长运动对高血压患者的心血管反应及脂蛋白代谢的影响,为高血压病运动处方的制定提供理论依据。方法:对45例老年高血压患者随机分成主要基线资料具有可比性的三组,A组采用等张练习,B组采用等长练习,C组采用等长练习+等张练习。观察运动训练16周后血压及血脂的变化。结果:所有受试者运动训练后血压降低(P<0.05)、血脂水平得以改善,其中以C组最为明显(P<0.01)。结论:等张运动与等长运动相结合的全面的运动康复训练方案可以有效改善高血压患者的血压与血脂水平,有利于高血压病的康复,是高血压病运动处方的首选。 相似文献
4.
以甘蓝(Brassiaca oleracea)为材料,取幼叶分离mRNA,反转录合成cDNA,以cDNA第一链为模板,通过PCR扩增,获得甘蓝磷酯酶D(Phosphorate Lipid Dehydrolase,PLD)HKD2功能区的基因片段.对其进行Blast分析,结果表明,分离的目的片段核苷酸序列与Genbank中报道的甘蓝PLD基因相比同源率为99.7%,只有2个碱基发生改变.将得到的PLD基因片段插入植物表达载体pAT940,构建了PLD基因反义表达载体pATC—rPLD,为下一步进行抗逆转基因作物选育打下基础. 相似文献
5.
黄芪和丹参清除自由基能力的研究 总被引:12,自引:0,他引:12
用电子顺磁共振(EPR)技术分别检测黄芪、丹参生药提取液对超氧阴离子自由基和脂质自由基的清除能力,结果显示一定含量的黄芪和丹参对超氧阴离子自由基和脂质自由基均有不同程度的清除作用,其中黄芪对脂质自由基的清除作用大于丹参,丹参对超氧阴离子自由基的清除能力强于黄芪。 相似文献
6.
J. W. M. Lagerberg J. VanSteveninck T. M. A. R. Dubbelman 《Cellular and molecular life sciences : CMLS》1997,53(3):257-262
The fluorescent dye Merocyanine 540 (MC540) is often used as a probe to monitor the molecular packing of phospholipids in
the outer leaflet of biomembranes. In a previous study we showed that the increased staining of erythrocytes with a perturbed
membrane structure was mainly due to an increase in the fluorescence yield of cell-bound MC540, rather than to an increase
of the number of bound molecules. Erythrocytes and ghosts exposed to continuous fluxes of H2O2 exhibited pronounced lipid peroxidation. Further, red blood cells subjected to this form of oxidative stress also showed
increased staining with MC540. It appeared that this was caused by a strong increase in binding of MC540, together with a
slight red shift of the fluorescence emission maximum and a small increase in the fluorescence yield of bound MC540. The changed
MC540 binding characteristics were not observed when lipid peroxidation was suppressed by the presence of the antioxidant
BHT in the incubation medium. However, open ghosts exposed to H2O2 showed no increase of MC540 binding, excluding a direct involvement of lipid peroxidation. Measurement of fluorescence emission
spectra and gel filtration studies showed that MC540 can bind to H2O2-exposed hemoglobin. Experiments with erythrocytes lysed in hypotonic medium after exposure to H2O2 revealed that peroxidation of lipids with H2O2 induced a non-specific permeabilization of the plasma membrane to MC540, thereby allowing MC540 to bind to the oxidatively
denatured, more hydrophobic hemoglobin. These results indicate that conclusions about packing of phospholipids in the outer
leaflet of the membrane based on increased MC540-staining should be drawn with care.
Received 27 September 1996; received after revision 5 November 1996; accepted 27 November 1996 相似文献
7.
A. A. Shaheen A. A. Abd El-Fattah M. Z. Gad 《Cellular and molecular life sciences : CMLS》1996,52(4):336-339
The level of malondialdehyde (MDA), an index of lipid peroxidation, and the antioxidants superoxide dismutase (SOD) and glutathione (GSH), as well as the activity of Na+, K+-ATPase, were assessed in whole rat brain after immobilization, anemic hypoxia (NaNO2) and 72 h starvation. The effect of these stressors on plasma glucose and corticosterone levels was also observed. Hypoxia and starvation stimulated the lipidj peroxide formation in braini as indicated by an increase in the level of MDA, being higher after starvation than hypoxia. Brain SOD activity was also increased in response to hypoxia and starvation while GSH content was only diminished ini hypoxia. However, neither MDA nor antioxidants were affected by immobilization. On the other hand, the activity of brain Na+, K+-ATPase was significantly increased by immobilization and hypoxia but decreased in starvation. A similar pattern of change was also observed in plasma glucose and corticosterone levels in response to these stressors. These results elucidate differences in the biochemical response of animals towards various types of stress, with increased lipid peroxide formation in hypoxia and starvation. 相似文献
8.
预辐照聚乙烯膜共接枝丙烯酸和苯乙烯单体的研究 总被引:3,自引:0,他引:3
利用预辐照聚乙烯膜产生的过氧化物与丙烯酸和苯乙烯单体共接枝,讨论了单体组成、单体浓度、预辐照剂量、接枝温度等对接枝共聚反应的影响。 相似文献
9.
李秀锦 《河北科技师范学院学报》1996,(4)
用TBA比色法测定了不同贮藏期鸡蛋蛋清及全蛋液中脂质过氧化物的含量。结果表明:随着贮藏时间的延长,鸡蛋全蛋液中脂质过氧化物的含量明显升高(P<0.01),但是蛋清中脂质过氧化物含量没有明显变化。新鲜鸡蛋全蛋液和蛋清中脂质过氧化物的含量分别为(2.70±0.48)、(0.324±0.047)μmol(MDA)/L全蛋液及蛋清中脂质过氧化物的含量在贮藏45d时分别为(4.18±0.47)、(0.336±0.044)μmol(MDA)/L;在贮藏70d时分别为(5.32±0.63)、(0.364±0.047)μmol(MDA)/L。 相似文献
10.
河南省高等院校离退休教职员工的血脂、血糖分析 总被引:1,自引:0,他引:1
作者采集了河南省高等院校部分离退休教职员工的血样数据,并进行了分析.围绕胆固醇、甘油三酯、血糖、血压和心率五项指标,按照正常值标准进行了判别.采用SPSS12.0进行了统计分析,进行了性别、年龄组间的差异显著性检验,并进行了血脂、血糖与血压、心率相关性分析.发现胆固醇和甘油三酯与收缩压和舒张压之间存在相关性. 相似文献