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Summary Cell and organotypical cultures are used to study the direct effect of serotonin and of ketanserin, a serotonin antagonist, on dermal and epidermal cells of embryonic chick skin. Ketanserin stimulates the increase in cell number and inhibits the differentiation, whereas serotonin stimulates differentiation and inhibits the increase in cell number. 相似文献
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通过结扎大鼠L5脊神经建立神经病理性痛模型.手术后第3日开始皮下注射酮色林(0.3 mg·kg-1)或其溶剂DMSO(体积分数为0.8%),每d1次,2周后灌流、取材,免疫组织化学实验显示神经结扎后L4背根神经节(DRG)和脊髓背角Ⅰ-Ⅱ层nNOS的表达均上调.然而皮下注射酮色林阻断5-HT2A受体,使L4 DRG和脊... 相似文献
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H. Beele H. Thierens B. Verhasselt L. de Ridder 《Cellular and molecular life sciences : CMLS》1990,46(10):1057-1060
Summary Chick feather bulbi cultured in vitro showed an increased DNA synthesis and a delayed keratinization after treatment with ketanserin, a serotonin2 antagonist with wound-healing properties. In contrast, serotonin stimulates keratinization of the keratinocytes in the bulbus. 相似文献
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