A new indolic antiauxin, α-(5,7-dichloroindole-3-)isobutyric acid: its chemical synthesis and biological activity

Summary A new potent antiauxin, -(5,7-dichloroindole-3-)isobutyric acid has been synthesized and shown to inhibit auxin-mediated elongation ofAvena coleoptiles and to stimulate root growth of rice seedlings. Its activity is stronger than -(p-chlorophenoxy)isobutyric acid and is comparable to that of 2,3,5-triiodobenzoic acid, which are typical antiauxins.     

The contents of the pygidial gland of the primitive antNothomyrmecia macrops (Hymenoptera:Formicidae)

Summary The principal constituent of the pygidial gland ofNothomyrmecia macrops is 3,7-dimethyloct-6-en-2-one, a substance not previously identified in insects. Also identified were 2,6-dimethylhept-5-enal, 2-nonanone, indole, -dodecalactone, and the hydrocarbons pentadecane, heptadecane, heptadecene and heptadecadiene, all in low nanogram quantities.     

Proopiomelanocortin expression in the skin during induced hair growth in mice

We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30–33 kDa recognized by anti -endorphin in late but not early anagen or telogen skin. By immunocytochemistry, -endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.     

Bicuculline and picrotoxin block γ-aminobutryic acid-gated Cl− conductance by different mechanisms

Summary Using isolated, internally perfused bullfrog dorsal root ganglion cells we have studied the dose-response curves for -aminobutyric acid (GABA) in the presence of internally or externally applied GABA antagonists. With external application of antagonists the inhibition of the GABA current by bicuculline was competitive and that by picrotoxin was noncompetitive. Picrotoxin but not bicuculline blocked when internally perfused.To whom reprint requests should be addressed.Acknowledgments. We thank Drs S. Minakami and S. Yasui for helpful discussions and comments.     

SL(2,R)上的Hausdroff-Young不等式

通过在SL(2，R)的对偶空间中引入测度，给出了SL(2，R)上的两个类似于R上的Hausdroff-Young不等式．     

《华山畿》故事所在地辨正

《华山畿》南朝乐府民歌是历来为人们所称颂的至爱至悲的千古绝唱，然而，关于其故事的发生地问题，迄今众说纷纭。或日“高淳华山”；或日“句容华山”。其实，依据《乐府诗集》、镇江地方志及有关实地考察等情况作全面辨析，可以断定：《华山畿》故事的发生地即在当今的镇江市新区石桥乡华山村。     

考虑节点非弹性变形的RC框架地震反应分析

钢筋混凝土梁柱组合体试验结果表明节点内纵筋滑移和节点剪切变形对组合体的抗震性能有明显影响,但框架的非弹性地震反应分析一般忽略了节点非弹性变形的影响.为了模拟节点区非弹性变形的影响,在纤维模型基础上采用在梁端附加零长度截面单元的方法,并通过σ-s本构模型考虑节点内梁纵筋粘结滑移,以及通过σ-sslip-shear本构模型同时考虑节点内纵筋滑移和节点剪切变形.考察了典型平面框架在罕遇地震下的非线性反应,对比分析了节点非弹性变形对框架整体和局部反应的影响.结果表明,考虑节点非弹性变形之后结构的最大顶点位移、最大层间位移角将增大或仅略有变化,梁端、柱端塑性铰数量将减少,梁、柱的转角延性需求总体而言将减小;地震作用下框架节点距离剪切失效尚有一定安全储备.框架地震反应大时忽略节点非弹性变形将导致明显误差,地震反应较小时可采用不考虑节点非弹性变形的常规有限元分析模型.     

日本林蛙部分生理生化指标的比较

本文介绍我们对日本林蛙(Rana j.japonica)在冬眠期(12～2月,5.5～8.5℃)与活动期(9～11月,12.5～24℃)的部分生理生化指标的比较.测定了血清、肝、脑、心肌和骨骼肌的乳酸脱氢酶(LDH)同工酶的相对活力(±SD)、血红蛋白浓度及红细胞数等指标.这些指标不仅存在明显的组织差异,也存在季节差异和种群差异.     

外骨骼式上肢康复机器人机构的研究

随着近年来偏瘫患者的增多,传统的康复医疗手段已经不能满足当前社会需求。在康复领域中,上肢康复尤为热点。人体上肢从事各种复杂、精细活动,它的运动功能直接影响人类的日常生活能力。提出一种两自由度的新型机构,对患者肘关节的屈、伸和前臂的前、后旋运动进行康复训练,以达到上肢康复的目的。     

长期精神紧张建立抑郁症模型

目的 采用长期精神紧张刺激建立动物抑郁症模型。方法 选用C57BL/6 J雄性4周龄小鼠17只,体质量(11. 05±1. 65) g,随机分为对照组、长期精神紧张刺激(LTMS)组。LTMS组单笼饲养并连续21 d每天给予猫惊吓3 h和剥夺睡眠12 h。实验组通过测定摄食量变化和高架十字迷宫实验、旷场实验、强迫游泳行为学变化来判断建模是否成功。结果 与对照组相比,LTMS组摄食量明显降低(P<0. 01),强迫游泳不动时间显著延长(P<0. 01)。旷场试验中,LTMS组小鼠穿越格数和直立次数均明显少于对照组,差异具有极显著性(P<0. 01)。高架十字迷宫实验中,LTMS组小鼠闭合臂停留时间明显延长,差异具有极显著性(P<0. 01);进入开臂次数比例减少,差异具有显著性(P<0. 05)。结论 长期精神紧张模型表现出行为绝望、活动能力下降、兴趣丧失、焦虑与抑郁症临床表现相似的症状,可作为抑郁症模型。