Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

（BN）n及SiB（n-1）Nn（n=2-11）稳定结构的研究

利用遗传算法及Gastreich提出的经验势函数,研究了（BN）n（n=2-11）和SiBn-1Nn（n=2-11）团簇的可能稳定结构,对能量较低的异构体在HF/STO-3G水平进行优化,得到了（BN）n（n=2-11）和SiBn-1Nn（n=2-11）团簇稳定结构单环及线状结构,并进一步分析了单环的结构特征及相对稳定性。     

日本人的“ラち”、“そと”意识与日语的时态转换

从日本人的“ラち”、“そと”意识角度出发，通过对川端康成、志贺直哉的几部小说进行分析统计，探讨日语在描写过去的事件中，插入“内时态‘る’形”的条件和原因。分析发现当作者为了使作品更生动，或是作者与作品中人物产生“同感”时，或是表达作者的主观思想、评论时，往往发生时态的转换。     

仿生食品工程学发展中的若干问题

本文简要介绍了仿生食品工程学建立的意义、性质和目前研究的主要内容。结合仿生食品工程学的需要,引出大食品的概念,并把分形理论引入仿生食品工程学研究。     

盐胁迫下灰绿藜叶片光合特性与叶绿体离子调节的研究

ＮａＣｌ处理后,灰绿藜整个叶片内Ｎ＾＋ａ和Ｃｌ＆－积累,但叶绿体内仅少量增加。叶绿体与叶片的Ｋ＾＋浓度都降低。     

固体电解质Li4+xBxSi1-xO4-yLi2O的合成及导电性

用溶胶－凝胶法制备了Li4 xBxSi1-xO4-yLi2O(x=0.1-0.6;y=0.0-0.5)离子导体材料，并用DTA－TG，XRD及交流阻抗等技术对样品进行了测试，结果发现用溶胶－凝胶法可降低Li4 xBxSi1-xO4的合成温度；随Li2O的掺入可增强基质材料的致密性并可提高其离子的导电性能。     

浅议共价键的部分离子性的估算

本文以四种方法为例，对二元共价化合物的离子性百分数的估算与讨论，初步找到估算共价键的部分离子性的思路和方法。对以电负性的大小确认二元共价键的离子性百分数给予新的补充     

高岭石和NaZr_2P_3O_（12）为基的矿物快离子导体

利用天然矿物高岭石为原料，采用高温固相应制备了Ｎａ１＋２ｘＡｌｘＺｒ２－ｘＳｉｘＰ３－ｘＯ１２系统的矿物快离子导体材料．Ｘ射线衍射表明，该材料具有Ｎａｓｉｃｏｎ型的骨架结构，２９８～６７３Ｋ离子电导率为００１～１ｍＳ／ｃｍ，激活能４０５３～５２１１ｋＪ／ｍｏｌ，当ｘ＝０５时呈现最高电导率，在６７３Ｋ时其电导率达到２５ｍＳ／ｃｍ，它的活化能为４０５３ｋＪ／ｍｏｌ     

过渡金属离子对PEG水溶液浊点温度的影响

本文用激光法测定了过渡金属离子对１％聚乙二醇（ＰＥＧ）水溶液浊点温度的影响，确定了不同浓度，不同金属离子作用下的浊点曲线。结果表明：浊点温度ｔｃ与金属离子质量摩尔浓度ｍ间存在着良好的线性关系。当阴离子相同时，２价阳离子的盐析能力与离子半径、离子势、离子构型以及水合离子构型有关。本文还考查了盐析作用机理。