全文获取类型
收费全文 | 4643篇 |
免费 | 238篇 |
国内免费 | 311篇 |
专业分类
系统科学 | 164篇 |
丛书文集 | 114篇 |
教育与普及 | 31篇 |
理论与方法论 | 21篇 |
现状及发展 | 177篇 |
研究方法 | 1篇 |
综合类 | 4671篇 |
自然研究 | 13篇 |
出版年
2024年 | 9篇 |
2023年 | 38篇 |
2022年 | 60篇 |
2021年 | 66篇 |
2020年 | 66篇 |
2019年 | 94篇 |
2018年 | 65篇 |
2017年 | 86篇 |
2016年 | 79篇 |
2015年 | 144篇 |
2014年 | 232篇 |
2013年 | 177篇 |
2012年 | 246篇 |
2011年 | 238篇 |
2010年 | 191篇 |
2009年 | 256篇 |
2008年 | 233篇 |
2007年 | 361篇 |
2006年 | 359篇 |
2005年 | 326篇 |
2004年 | 241篇 |
2003年 | 225篇 |
2002年 | 194篇 |
2001年 | 166篇 |
2000年 | 139篇 |
1999年 | 123篇 |
1998年 | 116篇 |
1997年 | 103篇 |
1996年 | 72篇 |
1995年 | 62篇 |
1994年 | 68篇 |
1993年 | 41篇 |
1992年 | 49篇 |
1991年 | 62篇 |
1990年 | 57篇 |
1989年 | 33篇 |
1988年 | 41篇 |
1987年 | 24篇 |
1986年 | 15篇 |
1985年 | 26篇 |
1984年 | 9篇 |
排序方式: 共有5192条查询结果,搜索用时 15 毫秒
1.
陈经强 《科技情报开发与经济》2015,25(8)
近年来,政府加大了对公共图书馆事业的投入力度,公共图书馆不再仅限于传统的图书借还功能,组织举办读者活动已成为图书馆的重点工作. 分析了公共图书馆举办的读者活动引不起读者兴趣的原因,提出了解决这一问题的对策和建议. 相似文献
2.
为了减少能量空洞和延长网络生命周期,在无线传感网中采用移动 Sink 的方式收集节点采集的数据是解决能
量效率问题的有效措施.采集路径的规划问题类似于旅行商问题,无法得到多项式时间的解.提出了将人工免疫算法和粒子群算法相结合,针对移动 sink 数据收集的路径规划问题寻求近似最优解,仿真结果表明: 与其他算法进行性能比较,所提出的优化算法能够有效减少能耗和缩短遍历路径. 相似文献
3.
合成一些新的有机磷化物,组成为(ArO)PhP(s)Y(Y=Cl、NCS).测定了mP、IR、HNMR并进行了元素分析.Ia的除草活性尚好. 相似文献
4.
Science Letters: A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen 下载免费PDF全文
It has been proposed that activation of Toll-like receptors (TLRs) plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 (TLR2) ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen (HDM). Mice were sensitized and challenged with Dermatophagoidesfarinae allergen (Der f), and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid (BALF). Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases. 相似文献
5.
ZHANG BaoMin ZHANG ShuiChang BIAN LiZeng JIN ZhiJun WANG DaRui 《科学通报(英文版)》2007,52(A01):77-91
Based on the researches on rock type, the mode of occurrence, diagnostic minerals and creatures, the sedimentary geochemistry and organic facies of Chinese marine source rocks from wells and outcrops, and on the research findings of developmental modes of foreign marine source rock, the authors consider that it is impossible to objectively make clear the formation mechanism of hydrocarbon source rock with high organic matter abundance by either single mode of preservation or high organic matter productivity. According to the Chinese geological features, the formation mechanism of the Neoproterozoic-Lower Paleozoic marine source rock is generalized into four modes, namely, thermal water activity-upwelling flow-anoxic; carbonate gentle slope-upwelling flow; xerothermic climate-brine euxinic milieu; and humid climate-retained euxinic milieu; as the Lower Cambrian undercompensation basin organic facies (the Tarim Basin, South China and southwestern margin of North China), carbonate gentle lime mud bound organic facies (the Upper Ordovician in Tazhong region of the Tarim Basin and the Lower Silurian in the Upper Yangtze Platform), the Middle Cambrian evaporation laggon organic facies (the Tarim Basin and the Upper Yangtze Platform), enclosed undercompensation terrigenous bay organic facies (the Middle-Upper Ordovician in the west of the Tarim Basin, the Lower Silurian Long- maxi Formation in the Upper Yangtze platform). Chinese marine sedimentations with lower organic matter abundance are generalized into two modes of consumption-dilution mode of open epicontinental sea and depletion-dilution mode of supercompensation basin. 相似文献
6.
《科学通报(英文版)》2006,(5)
QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP (QSAR) IS A VERY IMPORTANT TOPIC FOR MANY SCIENTIFIC FIELDS AND CAN BE TERMED AS QUANTITATIVE SEQUENCE ACTIVITY MODELS(QSAM)[1] WHEN REFERRED TO THE RESEARCH ON RELATION- SHIPS BETWEEN STRUCTURES AND ACTIVITIES OF BIOLOGICAL MOLECULES, SUCH AS PROTEINS, AND NUCLEIC ACIDS. HOW- EVER, IT IS VERY DIFFICULT TO ESTABLISH A QSAM MODEL,… 相似文献
7.
合成了9个未见文献报导的四氯乙基硫代磷酰胺酯,并对它们的合成、结构和性质以及杀蚜虫、线虫活性等进行了初步研究。 相似文献
8.
李云喜 《科技情报开发与经济》2006,16(14):128-129
介绍了作业成本法的特点,从5个方面探讨了作业成本法与传统成本法的差别,指出作业成本法具有一定的先进性。 相似文献
9.
R. Poggioli A. V. Vergoni A. Bertolini 《Cellular and molecular life sciences : CMLS》1985,41(2):265-266
Summary Hydrochlorothiazide, acutely injected in rats, has a weak analgesic activity per se and potentiates and prolongs the antinociceptive effect of morphine.This work was supported in part by grants from Consiglio Nazionale delle Ricerche, and by Ministero della Pubblica Istruzione, Roma. 相似文献
10.
新中国成立以来,在中日关系发展的不同阶段,中国一直处于主动地位,积极推动双边关系的发展。而日本则时而主动,时而被动,时而同时具有主动与被动的两面性。要使中日关系朝着友好合作伙伴的方向健康发展,同需两国的积极主动。 相似文献