Blockade by zinc ions of K+-induced contraction and calcium in guinea pigTaenia coli

Preincubation with 0.3 mM Zn²⁺ markedly inhibited both the tonic response and Ca²⁺ binding at low affinity sites induced by K⁺ (60 mM), with smaller effects on the phasic response and the high affinity Ca²⁺ sites, inTaenia coli. However, when the muscle was kept in Zn²⁺-containing medium following the first stimulation with the K⁺, the phasic response and the high affinity Ca²⁺ sites were more severely inhibited during the second stimulation with K⁺. This probably indicates that Zn²⁺ reduced the tonic tension response to K⁺ mainly by inhibiting Ca²⁺ influx at the cell membranes ofTaenia coli. However, when Zn²⁺ is continuously present, Ca²⁺ is not supplied at the storage sites and is not available for the phasic response to a second stimulation with K⁺.     

全膀胱切除-回肠新膀胱术26例报告

目的：探索全膀胱切除术后保留较好生活质量的手术方法,方法：按经典方法行全膀胱切除术,但术中尽量保留膀胱外括约肌及膜部尿道,并取约60cm带血管蒂的末段回肠,于肠系膜对侧缘纵形剖形成肠片,再将该肠片以“W”形折叠、,缝合为球形的新膀胱。双侧输尿管断端吻合于球形新膀胱、新膀胱的底部与尿道残端吻合。结果：1994．4－2000．4进行该手术26例,其中23例术后能自控排尿、无尿失禁、每次排尿量200－600mL。3例术后排尿困难。所有患者术后血电解质基本正常。B超检查无肾、输尿管扩张积水,膀胱造影无膀胱输尿管返流,膀胱尿道镜检查无尿道肿瘤复发。结论：新膀胱术术后有良好的排尿功能,膀胱容量大、压力低、自控排尿功能好,术后并发症少,是浸润性膀胱癌手术方式的一个优良选择。