径向井排引导水力压裂裂缝扩展机理研究

为探究径向井排系统对裂缝的影响，明确水力裂缝的扩展规律，利用扩展有限元理论建立了流固耦合三维裂缝扩展模型，模拟了受径向井排引导的水力裂缝扩展过程。重点分析了3种影响因素（径向井排方位角、水平地应力差、径向井孔径）对水力裂缝的引导机理。首次提出了"引导因子"的概念，并将其作为有效评价径向井排引导效果的量化参数。研究发现，径向井方位角、水平地应力差、径向井井径会对水力裂缝的引导效果产生影响：较小的径向井方位角、水平地应力差以及较大的井径都使径向井排具有较强的引导能力和较好的引导效果，反之亦然。同时，较大井径对增加水力裂缝宽度有明显作用。最后，利用大尺寸真三轴水力压裂模拟试验证实了数值模拟结果具有一定的准确性。     

重卡驱动桥壳疲劳稳健性与轻量化设计

驱动桥壳轻量化设计对于提高承载能力、降低生产成本具有重要的意义.本文在驱动桥壳有限元分析和疲劳分析计算的基础上建立驱动桥壳多目标优化模型，对重型卡车驱动桥壳进行参数化设计，建立正交试验表，利用田口方法和综合评价方法对驱动桥壳的疲劳性能稳健性和质量进行优化设计.优化结果表明，此方法可以应用于驱动桥壳的多目标优化，优化后驱动桥壳的疲劳稳健性能得到提高，减轻了质量，因此节约了桥壳材料，降低了生产和运营成本，提高了设计水平.     

带有临界增长的Kirchhoff方程极小能量变号解的存在性

为了深入研究Kirchhoff方程的性质,讨论了带有Hartree项和临界增长非线性项的Kirchhoff方程极小能量变号解的存在性。利用能量泛函在变号Nehari流形上的下确界C_λ收敛于0,得到空间E紧嵌入L~6(R~3)这一技术性结果。结果表明,利用限制变分方法和定量形变引理获得极小化序列对应的极小值点是该问题的非平凡解。研究方法在理论证明方面得到了良好的结果,对研究其他Kirchhoff方程解的存在性有一定的指导意义。     

钢筋混凝土结构板角斜裂缝分析

分析现浇钢筋混凝土结构中经常出现的整个建筑结构阳角楼板的 4 5°上下贯通斜裂缝的产生原因 ,并提出解决问题的设计和施工措施     

中医药抗运动性疲劳的研究现状

目前,丰富医学界对中医药抗运动疲劳的研究主要有两方面一、中医对运动性疲劳的诊治;二、中药对运动性疲劳的作用.文章对这两方面的研究进展进行了综述,为进一步的研究提供了参考依据     

1151系列式传感器上毛细管的疲劳寿命对比试验

设计了1151系列电容式传感器上非标准件的疲劳寿命对比试验,对铂-铑合金毛细管和铂-铱合金毛细管试件进行对比试验。采用等强度悬臂梁对试件施力,电阻应变片接收施力反馈信号,并采取多项措施提高试验精度。结果表明,铂-铱合金毛细管可以代替铂-铑合金毛细管。     

QY16汽车起重机主梁断裂失效分析

利用断裂力学理论和试手段对ＱＹ１６汽车起重机主梁断裂失效进行分析，找出断裂的主要原因为焊缝开裂。     

层板复合材料疲劳性能测试实验

根据层板复合材料的性能与具体的铺层形式有关的特点 ,介绍了在层板复合材料疲劳性能测试中试件准备注意事项、疲劳性能测试的内容和实验控制程序的要求 ,以及为缩短实验时间、优化层板复合材料疲劳剩余强度和疲劳剩余刚度分析模型的参数估计 ,并减少测试所需试件数量的合理试件数的确定方法 .     

Specific anti-tumor effect induced by attenuated Salmonella typhimurium vaccine expressing extracellular region of vascular endothelial growth factor receptor 2

The purposes of this research were to study the stable expression of exogenous gene encoding therapeutic protein in attenuated Salmonella typhimurium, observe the metabolism of oral gene vaccine carried by attenuated Salmonella typhimurium in BALB/c mouse, and investigate the feasibility of prevention and treatment of tumors by the recombinant bacteria. Recombinant plasmid pcDNA3.1 VEGFR2(n1-7) was transformed into competent attenuated Salmonella typhimurium SL3261 to develop oral DNA vaccine SL3261-pcDNA3.1 VEGFR2(n1-7). To observe whether the exogenous gene can be expressed in the recombinant bacteria, PCR was performed to amplify the CMV promoter of the eukaryotic expression vector as the proof of stable expression of exogenous protein; transmission elec- tron microscopy (TEM) was applied to observe the morphology of the recombinant bacteria to confirm that the exogenous gene has no impact on the growth of the bacteria, and then BALB/c mice were immunized with the gene vaccine. After inoculation of the gene vaccine, the recombinant bacteria SL3261 could be detected in the tissues such as small intestine, colon, liver and spleen. And then, mice in each group were challenged with tumor cells. The results of animal experiment showed that tumor growth of the mice in experimental group was inhibited and survival time of immunized mice was prolonged compared with control groups. A higher lymphocyte infiltration in tumors from animals treated with DNA vaccine was observed. Immunohistochemical analysis of tumor samples revealed an en- hanced accumulation of CD8 cytotoxic T lymphocytes, as well as an increase in CD4 cells in the tumors of animals treated with the oral gene vaccine compared to tumors from control group mice. Ultrastructure of the tumor tissue showed that tumor cells in the samples of the immunized mice were well-differentiated. Our research confirmed that the exogenous gene can be stably expressed in the attenuated Salmonella typhimurium and has no impact on the growth of the recombinant bacteria; the exogenous gene can de delivered to the host by attenuated Salmonella typhimurium to produce anti-tumor effect with no obvious cytotoxity to the host. In this study, it is established that attenuated Salmonella typhimurium could be used as a vector for oral gene vaccine, and our study provided a theoretical basis for the body distribution and the metabolism of the recombinant bacteria. This strategy may provide a simple, safe and effective way for the prevention and treatment of tumors.     

确定威布尔分布三参数的一种计算方法

威布尔分布是描述部件寿伞的一种极为主要的分布,本文对确定威布尔分布的三参数,给出了一种试探性算法,方法简单、实用。