物理精炼菜籽油的前处理——菜籽油的物理精炼研究(Ⅱ)

本课题采用正交试验方法,对脱胶添加剂和国产脱色白土的种类、用量及其他操作条件进行筛选试验研究,将试验结果对贵州产二级毛菜籽油进行前处理,经水蒸汽精炼后可以制得合符标准的外销色拉油。     

Pharmacodynamic profile of CQP 201-403, a novel 8α-amino-ergoline

Summary The profile of action in animals of CQP 201-403, a novel 8-amino-ergoline, is in most aspects that of a very potent dopaminomimetic, both as a prolactin secretion inhibitor, and at the levels of the CNS and the cardiovascular system. Qualitatively CQP 201-403 differs slightly from bromocriptine and apomorphine in its effects on the CNS (no influence on serotonin metabolism in the rat cortex; induction of masculine mounting behavior in rats) and the cardiovascular system of the dog (reflex tachycardia in response to a blood-pressure fall). In man the new compound proved to be highly active in lowering prolactin serum levels and to be more potent than bromocriptine (Parlodel^®).In memory of Dr Annemarie Closse, who died 14 June 1987.     

Endorcine cells producing regulatory peptides

Summary Recent data on the immunologication of regulatory peptides and related propeptide sequences in endocrine cells and tumours of the gastrointestinal tract pancreas, lung, thyroid, pituitary (ACTH and opioids), adrenals and paraganglia have been revised and discussed. Gastrin, xenopsin, cholecystokinin (CCK), somatostatin, motilin, secretin, GIP (gastric inhibitory beenrevised and discussed. Gastrin, xenopsin, cholecystokinin (CCK), somatostatin, motilin, secretin, GIP (gastric inhibitory polypeptide), neurotensin, glicentin/glucagon-37 and PYY (peptide tyrosine tyrosine) are the main products of gastrointestinal endocrine cells; glucagon, CRF (corticotropin releasing factor), somatostatin, PP (pancreatic polypeptide) and GRF (growth hormone releasing factor), in addition to insulin, are produced in pancreatic islet cells; bombesin-related peptidesare the main markers of pulmonary endocrine cells; calcitonin and CGRP (calcitonin gene-related peptide) occur in thyroid and extrathyroid C cells; ACTH and endorphins in anterior and intermediate lobe pituitary cells, -MSH and CLIP (corticotropoin-like intermediate lobe peptide) in intermediate lobe cells; met- and leu-enkephalins and related peptides in adrenal medullary and paraganglionic cells as well as in some gut (enterochromaffin) cells; NPY (neuropeptide Y) in adrenalin-type adrenal medullary cells, etc.. Both tissue-appropriate and tissue-inappropriate regulatory peptides are produced by endocrine tumours, with inappropriate peptides mostly produced by malignant tumours.     

Nitric oxide-related pancreatic endocrine responses to hyperglycaemia in the conscious calf

Mean plasma insulin concentration was reduced and mean plasma glucose concentration increased following the administration of N-nitro-L-arginine methyl ester (L-NAME; 100 mol kg^–1 i.a.) in conscious calves given continuous infusions of exogenous glucose (30–60 mol min^–1 kg^–1 i.v.). It is concluded that the rise in plasma insulin concentration which occurs in these animals in response to glucose is mediated, at least in part, by a nitric oxide-related factor (NOx).     

不同药剂对破除播娘蒿种子休眠的效应

播娘蒿种子休眠的自动存作约需半年时间。研究了不同药剂对破除其休眠的效应。结果表明：药剂浸种可迅速打破其种子休眠,其中以３０％浸种３０ｍｉｎ,作用最显著,破眠率可达９３％,其次是３００×１０＾６ＧＡ浸种２４ｈ,ＮａＯＨ,ＰＥＧ,ＰＶＡ等作用较弱。     

硝基芳烃化合物对大型蚤的联合毒性

分别测定了2，4-二硝基甲苯(2，4-DNT)与5种硝基芳烃化合物对大型蚤的单一毒性及二元混合物的联合毒性，采用毒性单位法评价了硝基芳烃化合物对大型蚤的联合毒性效应．结果表明，5种二元混合物的联合毒性以相加作用为主，说明此类化合物可能是以相似的方式作用于大型蚤．     

THYESS法结合QSAR分析对环境内分泌干扰性物质的筛检研究

利用THYESS法对几种典型的环境内分泌干扰物质的毒理活性进行了定量筛检，并进一步结合量子化学对被检物质作了QSAR分析．结果表明，用THYESS法筛检出的环境内分泌干扰物质存在着良好的毒活性．反应剂量关系．这种测定方法再结合量子化学的QSAR分析，有望成为获得大量环境样品中EDCs毒害数据的一种良好方法．     

两种贮藏温度及药剂处理对藏茵陈种子活力的影响

将川西獐牙菜,椭圆叶花锚,抱茎獐牙菜种子贮存在(18±5℃)和(0～4℃)下18个月。用0 2%CaCl2和2%KNO3溶液浸泡24h,进行电导率、TTC还原量及发芽率测定,结果表明:①两种温度下贮存的种子,除电导率差异极显著外(P<0 01),其余各项指标均不显著(P>0 05);②经药剂处理的种子具有较高的发芽率;两种药剂以0 2%CaCl2效果较好,发芽率平均提高20%;③同一温度贮存的川西獐牙菜和椭圆叶花锚种子,经药剂处理后的电导率极显著高于对照(P<0 01),药剂处理后TTC还原量差异不显著(P>0 05)。     

一种基于睾丸素分泌调节原理的双层结构控制器

基于下丘脑-垂体-睾丸素内分泌调节回路模型,提出了一种双层结构控制器.该双层结构控制器包括一级控制器和二级控制器.一级控制器根据控制偏差的大小,动态调整二级控制器的给定值输入,从而能够迅速、稳定地消除控制偏差.实验结果表明,该双层结构控制器的控制性、适应性等较普通PID控制器优越.     

前瞻性定制化学品

定制化学品的市场需求要求定制化学品制造商不断进行调整，新颖的精细化学品以及新工艺、创新技术也不断涌现。本文介绍了近两年新研究开发的富有魅力的精细化学品和关键技术。