Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

（BN）n及SiB（n-1）Nn（n=2-11）稳定结构的研究

利用遗传算法及Gastreich提出的经验势函数,研究了（BN）n（n=2-11）和SiBn-1Nn（n=2-11）团簇的可能稳定结构,对能量较低的异构体在HF/STO-3G水平进行优化,得到了（BN）n（n=2-11）和SiBn-1Nn（n=2-11）团簇稳定结构单环及线状结构,并进一步分析了单环的结构特征及相对稳定性。     

国内橡胶助剂研究开发情况及发展趋势

全面介绍了我国橡胶助剂的品种、性能、生产厂家等，根据现状对今后橡胶助剂工业的发展提出了预测和建议。     

日本人的“ラち”、“そと”意识与日语的时态转换

从日本人的“ラち”、“そと”意识角度出发，通过对川端康成、志贺直哉的几部小说进行分析统计，探讨日语在描写过去的事件中，插入“内时态‘る’形”的条件和原因。分析发现当作者为了使作品更生动，或是作者与作品中人物产生“同感”时，或是表达作者的主观思想、评论时，往往发生时态的转换。     

SL(2,R)上的Hardy-Littlewood极大函数的性质

本文给出了SL(2,R)上的Hardy-Littlewood极大函数mf的定义,利用Ergodic定理证明了Hardy-Littlewood极大函数的强(p,p)型性质,p>1.     

Stability of the Sarcin/Ricin domain of 28S RNA in rat ribosome under hydrostatic pressure

Under 2 100 bar of hydrostatic pressure, KNA N-glycosidase can still cleave the N-C bond of adenosine at position 4324 in R/S domain of 28S RNA in rat ribosome, demonstrating that high pressure has no effect on the tertiary structure of S/R domain.     

北方山溪鲵与隆肛蛙视网膜显微结构的观察比较

为探讨北方山溪鲵和隆肛蛙视网膜结构与生活习性、捕食方式的关系，用光镜观察了这两种动物视网膜的结构，测量各层厚度、3个核层胞核的层数及胞核直径．结果表明，山溪鲵与隆肛蛙视网膜虽然各核层的层数相似，但隆肛蛙的胞核直径明显小于山溪鲵，致使两种动物在3个核层和2个网层的厚度上存在明显差异．从视网膜结构分析其机能，依赖于视觉捕食的隆肛蛙，视网膜具有较高的视敏度；捕食时以嗅觉为主、视觉为辅的山溪鲵，视网膜则具有较高的光敏度．显示了视网膜结构机能与各自的捕食方式的适应性．     

铜锌铝合金"类流态"振荡时间序列的相空间重构

摘为了揭示固体“类流态”的非线性振荡机理，利用普通的光学显微镜、原子力显微镜（AFM）对Cu—Zn-Al合金表面金相组织进行了观察和研究．用计算机编程技术构建了系统的非线性动力模型，重构了系统的相空间．结果表明，系统存在混沌吸引子，最小嵌入维数为5；控制误差在5％以内，非线性模型可以由原始数据的1000个点预测100个点，超过100点时误差变大，说明了短期的非线性预报的可行性；R／S方法对时间序列演化特征进行分析，得到拟合线近似为直线，且斜率为0．86，表明“类流态”序列具有明显的Hurst效应，H〉1／2，是分式布朗运动，运动具有较强的持续性．     

Rn中有界域上调和函数的积分表示

在前人讨论R^n中闭逐块流形上高斯积分的边界性质的基础上，建立了R^n空间中有界域上可微分函数和调和函数的积分表示公式．     

某些特殊函数族支撑点的性质

本文研究了GL函数族和负实系数单叶函数族SR-支撑点的性质，得到了GL函数族支撑点的映照性质，并且获得了负实系数单叶函数族SR-的支撑点的形式．