排序方式: 共有4条查询结果,搜索用时 0 毫秒
1
1.
CyclinE反义RNA抑制乳腺癌细胞增殖及P21wafl转录水平 总被引:2,自引:0,他引:2
利用反义RNA抑制基因表达的技术,发现cyclinE基因在表达受到抑制后,乳腺癌细胞增殖速率和致瘤性明显下降,结果还表明cyclinE基因的抑制,可使p21wafl的转录水平上升,由此说明cyclinE的异常与乳腺癌的发生有着密切的关系,在细胞周期调控上p21wafl的转录受到cyclinE表达水平的明显影响. 相似文献
2.
利用反义RNA抑制基因表达的技术 ,发现cyclinE基因在表达受到抑制后 ,乳腺癌细胞增殖速率和致瘤性明显下降 ,结果还表明cyclinE基因的抑制 ,可使p2 1waf1的转录水平上升 ,由此说明cyclinE的异常与乳腺癌的发生有着密切的关系 ,在细胞周期调控上 p2 1waf1的转录受到cyclinE表达水平的明显影响 . 相似文献
3.
Effects of CDK4 antisense RNA on Human breast cancer cell proliferation and expression of cyclinD1, cyclinE and CDK2 总被引:1,自引:0,他引:1
The role of CDK4 in human breast cancer cell proliferation and expression of cyclinD1, cyclinE and CDK2 has been investigated
using inhibition of CDK4 expression by antisense RNA. When CDK4 expression was inhibited, the rate of cell proliferation and
tumorigenecity decreased apparently. This indicates that CDK4 plays an important role in formation and development of breast
tumor. The results of Northern blot analysis showed that the levels of cyclinDl and CDK2 mRNAs changed slightly whereas the
level of cyclinE mRNA decreased obviously. It is suggested that the expression of CDK4 is necessary for imction of cyclinE
expression. Thus, inhibition of CDK4 expression affects not only the role of CDK4 itself but also the role of other genes. 相似文献
4.
《科学通报(英文版)》1999,44(6):541-541
The role of CDK4 in human breast cancer cell proliferation and expression of cyclinD1, cy-clinE and CDK2 has been investigated using inhibition of CDK4 expression by antisense RNA. When CDK4 expression was inhibited, the rate of cell proliferation and tumorigenecity decreased apparently. This indicates that CDK4 plays an important role in formation and development of breast tumor. The results of Northern blot analysis showed that the levels of cyclinDl and CDK2 mRNAs changed slightly whereas the level of cyclinE mRNA decreased obviously. It is suggested that the expression of CDK4 is necessary for induction of cyclinE expression. Thus, inhibition of CDK4 expression affects not only the role of CDK4 itself but also the role of other genes. 相似文献
1