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1.
The development of stamen is an important stage during the sexual reproduction in higher plants. Studying the genes that predominantly
or even specifically expressed in stamens will aid in undestanding the molecular mechanism of stamen development. The structure
of a rice CHS-like gene (D5) which predominantly expressed in anthers has been analysised, showing high structural similarity
with two other anther-specific genes (A1 and BA42) fromBrassica napus. Northern analysis also reveals that the three genes share a similar expression pattern and that the expression of D5 may
relate to the early development of pollens. It is concluded that D5, A1 and BA42 represent a group of diverged CHS-like genes
which are related to stamen development. 相似文献
2.
M. Rizzardini A. Ferraroli D. Dal Fiume L. Cantoni 《Cellular and molecular life sciences : CMLS》1984,40(12):1390-1392
Summary Im male rats hepatic cytochromes b5 and P-450 were reduced at different times after treatment with cyclophosphamide (CP) (200 mg/kg i.p. for 3 days). In contrast, microsomal heme did not change until 48 h after the last dose of CP, leading to accumulation of heme in a non-cytochromal form. Parallel to the above changes the heme metabolism showed derangement: -aminolaevulinate synthase, the rate-limiting enzyme in heme synthesis, was depressed and heme oxygenase, the enzyme which catalyzes the oxidative degradation of heme, was increased. 相似文献
3.
采用NADPH-黄递酶组织化学法对草鱼、牛蛙、家鸡和大鼠小肠肌间神经丛内NOS阳性神经元的分布进行了比较研究.结果表明,NOS阳性产物在草鱼肌间神经丛中未见分布,而在其它几类动物中阳性反应明显.但在不同动物NOS阳性神经元的形态、分布、密度及神经纤维的分布存在差异.在牛蛙、家鸡和大鼠的小肠肌间神经丛中,NOS阳性神经元的分布从分散到集中,形态呈现由不规则形到规则形再到不规则形的复杂变化;神经节从无到有,神经网络由不发达趋于发达;而在每种动物中,NOS阳性神经元的密度沿肠道由前向后基本呈上升趋势,这种节段性的差异牛蛙极显著,家鸡和大鼠则不甚显著.实验结果提示,随着动物的进化,一氧化氮能神经元在肠肌间神经丛中的分布也更加复杂而有序,从而使胃肠道的调节更加精确. 相似文献
4.
5.
植物螯合肽(phytochelatins,PCs)在植物解除重金属的毒性方面具有重要作用,是以谷胱甘肽为底物,在植物螯肽合成酶(phytochelatin synthase,PCS)催化下合成的.作者已经克隆得到的长喙田菁(Sesba-nia rostrata)植物螯合肽合成酶SrPCS4 cDNA长为1035 bp,其ORF编码177个氨基酸,以pHANNIBAL及pART27为基础,构建了CaMV35S启动子驱动的SrPCS4基因植物表达载体pAM25,采用电击转化方法将pAM25导入根癌农杆菌EHA105,并通过改良叶盘转化方法用该菌株对烟草进行了转化,对转基因烟草进行了PCR与northern-blot检测,研究结果表明得到了表达该基因的烟草,但表达该基因的烟草不能够提高对Cd的抗性. 相似文献
6.
N. Asano 《Cellular and molecular life sciences : CMLS》2009,66(9):1479-1492
A large number of compounds mimicking the structures of monosaccharides or oligosaccharides have been discovered from natural
sources. Such sugar mimics inhibit carbohydrate-degrading enzymes because of a structural resemblance to the sugar moiety
of the natural substrate. Carbohydrate-degrading enzymes are involved in a wide range of important biological processes, such
as intestinal digestion, posttranslational processing of the sugar chain of glycoproteins, their quality control mechanisms,
lysosomal catabolism of glycoconjugates, and some viral infections. It has now been realized that inhibitors of the enzymes
have enormous therapeutic potential in diabetes and lysosomal storage disorders. In this review, the general bioactivity,
current applications, and the prospects for new therapeutic applications are described.
Received 27 August 2008; received after revision 08 November 2008; accepted 03 December 2008 相似文献
7.
Glycogen synthase kinase 3β and Alzheimer’s disease: pathophysiological and therapeutic significance 总被引:3,自引:0,他引:3
Balaraman Y Limaye AR Levey AI Srinivasan S 《Cellular and molecular life sciences : CMLS》2006,63(11):1226-1235
Alzheimer’s disease (AD) is a neurodegenerative disorder associated with cognitive and behavioral dysfunction and is the leading
cause of dementia in the elderly. Several studies have implicated molecular and cellular signaling cascades involving the
serine-threonine kinase, glycogen synthase kinase β(GSK-3β) in the pathogenesis of AD. GSK-3β may play an important role in
the formation of neurofibrillary tangles and senile plaques, the two classical pathological hallmarks of AD. In this review,
we discuss the interaction between GSK-3β and several key molecules involved in AD, including the presenilins, amyloid precursor
protein, tau, and β-amyloid. We identify the signal transduction pathways involved in the pathogenesis of AD, including Wnt,
Notch, and the PI3 kinase/Akt pathway. These may be potential therapeutic targets in AD.
Received 19 December 2005; received after revision 24 January 2006; accepted 6 February 2006 相似文献
8.
概述了真菌聚酮合酶几种有代表性的新分类,这些分类对于进一步认识、改造和利用真菌聚酮合酶以及开发真菌聚酮化合物资源等方面具有重要意义。 相似文献
9.
The structure-based sequence motif of the distant proteins in evolution, protein tyrosine phosphatases (PTP) Ⅰ and Ⅱ superfamilies, as an example, has been defined by the structural comparison, structure-based sequence alignment and analyses on substitution patterns of residues in common sequence conserved regions. And the phosphatases Ⅰ and Ⅱ can be correctly identified together by the structure-based PTP sequence motif from SWISS-PROT and TrEBML databases. The results show that the correct rates of identification are over 98%. This is the first time to identify PTP Ⅰ and Ⅱ together by this motif. 相似文献
10.
胰岛素样生长因子结合蛋白(IGFBP7)是胰岛素样生长因子结合蛋白超家族(IGFBPs)中一名新成员。与其他结合蛋白一样,它能与胰岛素样生长因子(IGFs)相结合,携带、转运IGF,延长IGF的半衰期,调控IGF的生物活性;更为重要的是,IGFBP7具有许多不依赖于IGF的生物作用,可参与多种类型的组织细胞的生长、发育、分化衰老与癌变等病理生理学过程。 相似文献