实验动物行业兽医现状分析

实验动物行业中,兽医体现在实验动物相关工作中的每一个环节,包括实验动物的日常管理、动物实验的设计、实验过程中动物健康保障和护理、实验动物福利的监督和管理、动物实验技术的应用、实验动物取材、施行安死术等。通过参阅相关文献资料,结合自身工作总结,就目前实验动物兽医现状进行分析,供各位同仁以参考。     

动物试验方法的专利申请

 为判断动物试验方法是否具备实用性，分析了中国关于实用性的相关规定，通过4个典型案例对动物试验方法是否属于非治疗目的的外科手术方法、是否具备实用性进行了分析，总结判断标准并给出了撰写权利要求的建议。在撰写动物试验方法的专利申请时，应当注意该方法的目的及该方法是否包含外科手术步骤，并针对该方法的不同情况采用不同的撰写策略。     

LehmerDH数在模p剩余系的分布

设 p≥ 3为素数 ,集合A ={a|1≤a 相似文献   

抗癌药物蓖麻油提取物的气相色谱分析

文[1]曾报道将蓖麻油提取物精制品制成乳剂和多相脂质体,进行动物体内外抗癌活性实验,结果表明该提取物具有较强的抗癌活性,但其抗癌活性成分的组成和含量尚不清楚.本实验就蓖麻油提取物的组成和含量进行气相色谱分析.     

白血病小鼠模型中P53、C-myc基因表达的变化研究

探讨DNA、RNA病毒诱导小鼠发生白血病的机制。用单纯疱疹病毒Ⅱ型（HSV－2）和C型RNA病毒诱导70只昆明小鼠，光学显微镜检测HSV－2、C型病毒诱导发生白血病的成功率。正常对照组为30只昆明小鼠。免疫组化法检测HSV－2、C型病毒致瘤后P^53、G－myc基因表达的变化。70只昆明小鼠中有47只发生白血病，成功率为67．1％。47只白血病小鼠P^53、C－myc蛋白阳性表达率均比正常对照组高（P＜0．05）；23只未形成白血病的实验组小鼠P^53、C－myc蛋白阳笥表达率均与正常对照组无显差异（P＞0．05）。HSV－2、C型病毒可以通过调节P^53、C－myc基因的表达从而诱导小鼠白血病的发生。     

Detecting myocardial ischemia with 2-D CVIB imaging method--an in vivo animal experiment study

A 2-D cyclic variation of integrated backscatter (CVIB) imaging method was established for detecting myocardial ischemia. To demonstrate the feasibility and validity of this method, animal experiments were conducted. Acute myocardial ischemia was induced by occluding left anterior descending coronary artery in 10 anesthetized open-chest dogs. While scanning the normal hearts and the ischemic hearts with a B scanner, digital radiofrequency data were acquired by a real-time acquisition system in synchronism. The offline analysis to the radio-frequency signal with the 2-D CVIB imaging method was performed to verify the consistency between the imaging result and the design of the experiment. In addition, 4 dogs in experiment were treated with the heart pacemaker in order to investigate the influence of changing in heart rate on the detection of ischemic myocardium with the proposed method. The experimental result showed that the 2-D CVIB imaging method succeeded in detecting the ischemic myocardium and is a new non-invasive way for the cardiologists to both quantitatively and visually evaluate the contractile performance of the myocardium.     

固相微萃取膜(SPMEE)在滥用药物检验中的应用

介绍一种全新的SPMEE技术SPMEE法，并对其在滥用药物检验中的应用进行了初步探讨。     

转基因动物专利:历史和存在的问题

回顾了转基因动物专利的发展历史，对欧美在转基因动物可专利性之历史演变过程中的几个转折点的成因作了技术、法律、经济和伦理角度的分析．     

颗粒饲料在太原动物园动物饲养中的应用

介绍了颗粒状配合饲料的性状,分析了全价颗粒饲料在饲喂动物中的优势,总结了颗粒饲料加工和使用中应注意的问题。     

Comparative aspects of structure and action of molluscan neuropeptides

A number of neuropeptides were isolated from the ganglia and muscles of molluscs, and their actions were examined. Diverse neuropeptides, in addition to several classical neurotransmitters, were suggested to be involved in the regulation of the anterior byssus retractor muscle ofMytilus. A wide structural variety of members of theMytilus inhibitory peptide family was observed in each of the generaMytilus, Achatina andHelix. Gly-Trp-NH₂, the C-terminal dipeptide fragment of the neuropeptide AGPWamide, showed a more potent action than the parent peptide in all of the muscles examined. Peptides related to some molluscan neuropeptides were found to be distributed interphyletically. Some neuropeptides containing ad-amino acid residue were found inAchatina andMytilus. These aspects of molluscan neuropeptides are thought not to be exceptional.