Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

（BN）n及SiB（n-1）Nn（n=2-11）稳定结构的研究

利用遗传算法及Gastreich提出的经验势函数,研究了（BN）n（n=2-11）和SiBn-1Nn（n=2-11）团簇的可能稳定结构,对能量较低的异构体在HF/STO-3G水平进行优化,得到了（BN）n（n=2-11）和SiBn-1Nn（n=2-11）团簇稳定结构单环及线状结构,并进一步分析了单环的结构特征及相对稳定性。     

消糜栓中青椒、血竭的薄层层析鉴别

采用酸提、碱化、萃取等步骤提取青椒中的生物碱类成分，以苯-醋酸乙酯-无水乙醇-氨水(体积比为24：3：1：O．5)为展开剂；采用醇提、酸溶、碱化、萃取等步骤提取血竭中的血竭素，以氯仿-甲醇(19：1)为展开剂．鉴别项下层析图谱清晰，阴性对照无干扰，专属性强，该法简便、准确、重现性好，可作为控制中药消糜栓中青椒、血竭质量的鉴别项。     

日本人的“ラち”、“そと”意识与日语的时态转换

从日本人的“ラち”、“そと”意识角度出发，通过对川端康成、志贺直哉的几部小说进行分析统计，探讨日语在描写过去的事件中，插入“内时态‘る’形”的条件和原因。分析发现当作者为了使作品更生动，或是作者与作品中人物产生“同感”时，或是表达作者的主观思想、评论时，往往发生时态的转换。     

海芋凝集素的理化性质鉴定

采用葡聚糖凝胶１００（ＳｅｐｈａｄｅｘＧ－１００）从天南星科植物海芋（Ａｌｏｃａｓｉａｏｄｏｒａ（Ｒｏｘｂ）Ｃ．Ｋｏｃｈ）中分离出了一种凝集素（简称ＡＯＬ）．ＡＯＬ对兔血有较强的凝集效果,而对各类型人血的凝集活力较弱,在３种糖蛋白中,猪甲状腺球蛋白对ＡＯＬ的凝血活力抑制最强;ＡＯＬ对培养人外周血白细胞的转化率高达７９％,超过对照ＰＨＡ的转化率;用ＳｅｐｈａｄｅｘＧ－２００柱测得ＡＯＬ的相对分子质量为３１５００;用癌细胞体外培养的方法证明了ＡＯＬ对肺腺癌细胞株Ｐ１８具有较强的直接杀伤能力．此外还发现ＡＯＬ对温度（８０℃以下）、变性剂（盐酸胍和脲）有较高的稳定性,在ｐＨ６～１０的范围内相当稳定．     

清中后期社会历史文化心态的展现——以小说《荡寇志》为例

《荡寇志》是清中后期保守士人面对西潮涌入、传统文化失落的集体性情感反应的产物,小说作者俞万春以捍卫中国传统文化的基本价值为己任,担负起了文化卫道的使命。但残酷的现实却撕碎了他加强君权、帝制,肃清内乱来重振国威的卫道美梦,小说《荡寇志》便展示了这一特定历史时期各种社会变革思潮下的社会历史文化心态。     

Description of rotational properties of the superheavy nucleus ^256,258,260Rf by projected shell model

Band structure of the Z = 104 nucleus 256Rf has been a recent research focus in nuclear physics. We performed projected shell model calculations for this and some other neighboring Rf isotopes. Specifically, we studied rotational properties of these nuclei and showed that variations in dynamic moment of inertia were sensitive to single-particle structures, which may be useful information for locating the anticipated island of stability. Electromagnetic transition properties were also calculated, and measurable quantities were predicted for further experimental test.     

DanHong Injection inhibits the development of primary abdominal aortic aneurysms in apoE knockout mice

Clinical observations indicate that DanHong Injection （DHI） can increase blood flow and reduce various syndromes in patients with cardiovascular disease. How- ever, it still needs to define the function of DHI and the involved mechanisms in details, such as the protective effect on the development of primary abdominal aortic aneurysms （AAAs）. In this study, we determined whether DHI is able to inhibit AAA in apoE knockout （apoE-/-） mice. Thirty apoE-/- male mice on high-fat diet （0.5 % cholesterol, 21% fat） were randomly divided into two groups and received i.p. injection of saline （100 μL/day） and DHI （100 μL/day）, respectively, for 16 weeks. At the end of experiment, we determined the development of atherosclerosis in en face aorta and aneurysms,pathological morphology of arterial wall, and serum lipid levels. We also determined the expression of monocyte chemoattractant protein-1 （MCP-1）, MMP-2, and MMP-9 mRNA in aortic wall using real-time RT-PCR. Our results indicated that high-fat diet induced the development of AAAs in apoE-/- mice, but the induction was totally blocked by DHI （P 〈 0.01）. The result of staining of abdominal aortic cross sections showed that DHI main- tained the collagen content in arterial wall, thereby pre- venting the animals from the development of AAA. Although DHI had little effect on serum total- and LDL- cholesterol levels, it reduced the expression of MCP-1, MMP-2, and MMP-9 mRNA in aortic wall （P 〈 0.01）. Taken together, our study suggests that DHI can inhibit the high-fat diet-induced AAA formation. The inhibitory effects may be related to the maintenance of the collagen content and inhibition of expression of AAA-related genes. Our study may suggest a new application of DHI in clinics.     

(λ,μ)-模糊粗糙子群

本文根据(λ,μ)-模糊正规子群定义了新的同余关系,由此提出了(λ,μ)-模糊粗糙子群和(λ,μ)-模糊粗糙正规子群的概念,并研究了它们的性质.     

COD测定废液中Ag2S04的回收循环利用研究

目的研究COD测定废液中Ag2SO4的回收和利用，实现资源的循环利用，提高利用效率，节约实验成本，减少环境污染。方法以COD测定废液为研究对象，将Ag2SO4通过NaCl转化为AgCl沉淀，再用Zn粒在酸性介质中进行还原，使AgCl转化为银粉；所得银粉在少量HN03存在的条件下，用浓H2S04氧化，将其转化为Ag2SO4，重新用于COD测定实验。结果通过一系列实验研究表明，有70％的银可以得到回收，所得Ag2SO4再次用于COD测定实验，标准样品的COD测定误差在许可范围之内；实际污水中COD的测定实验结果表明，Ag2SO4循环使用的测定误差平均为7．4％。结论实验证明回收的Ag2SO4可以作为COD测定实验的催化剂循环使用，可操作性良好，在节约实验成本的基础上，对于环境保护、减少污染物排放量方面有显著效果。但是COD测定结果的偏差较大，重现性有待进一步改进提高。