Cadherin-based biomaterials: Inducing stem cell fate towards tissue construction and therapeutics

The precise regulation of cell fate by biomaterials is one of the core focuses in tissue engineering and regenerative therapeutics. Cell fate is controlled by the niche signaling cues, including growth factors/morphogens, direct cell-cell contact, and extracellular matrix components. Here, we discuss how to bio-mimic cell-cell interaction by tailoring the interface of biomaterials to design effective scaffolds. Cadherins, as a key cell membrane protein family mediating the intercellular adherens junction, have attracted extensive attention in the functional modification of biomaterials. Therefore, cadherin-based biomaterials, their ability to modulate stem cell fate, and their applications in regenerative medicine are reviewed. Furthermore, we provide an outlook for exploiting the bio-mimic biomaterials in advanced cell therapeutics.     

主从JK触发器微机模拟系统设计

用Ｃ语言设计了一个主从ＪＫ触发器的模拟系统，给定ＣＰ时钟脉冲，通过输入Ｊ、Ｋ波形、程序利用ＪＫ触发器的逻辑关系，绘出相应的输出波形，此模拟系统解决了触发器的动态演示问题。     

双功能的MnSOD和MnCAT的模拟物-1,4-二亚甲基苯并咪唑-1,4,7-三氮环壬烷合锰配合物的研究

合成了新的锰配合物[MnLCl]*ClO4*CH3OH (L=1,4-二亚甲基苯并咪唑-1,4,7-三氮环壬烷),测定了该配合物的单晶结构,用ES-MS、EPR、CV、UV等多种手段进行了表征.测定了该配合物的超氧化物歧化酶(SOD)活性及锰过氧化氢酶(MnCAT)的活性. 实验结果表明,该配合物既具有良好的超氧化物歧化酶活性,又具有好的过氧化氢酶活性.