Effect of fasting on skeletal muscle triglyceride content

Summary The effect of prolonged food deprivation on the triglyceride level in different types of skeletal muscle was studied in the rat. It has been found that fasting gradually reduces the triglyceride content in each muscle type. It is concluded that i.m. triglycerides play an important role as energy fuel during fasting.     

甘油三酯人群分布水平抽样调查与统计分析

通过多阶段抽样调查法，从广东佛山石湾区正常人群中取３０９例进行甘油三酯（ＴＧ）测检，采用统计分析的方法，揭示出ＴＧ在正常水平的人占６６％，ＴＧ异常增高的人占３４％，ＴＧ增高在３ｍｍｏｌ／Ｌ以上组的收缩压和舒张压均高于正常组，提示高ＴＧ与高血压相关；５０岁后年龄组ＴＧ异常率明显高于以前组，提示高ＴＧ血症与老年人密切相关；在ＴＧ增高的人群中，男性多于女性，男性异常率是３９．８％，女性异常率是２３％。各     

某天然矿泉水对实验性高脂大鼠血脂水平的影响

目的探讨预防性饮用某天然矿泉水对实验性高脂大鼠血脂水平的影响。方法 28只5周龄的雌性清洁级SD大鼠禁食12h后,内眦采血,测血清中的胆固醇(TC),根据TC水平随机分为高脂模型实验组和高脂模型对照组,每组14只。饲喂髙脂饲料的同时,高脂模型实验组自由饮用某天然矿泉水,高脂模型对照组自由饮用自来水,饮用某天然矿泉水第30 d和40 d,分别禁食12 h后,内眦采血,Autolab 1.0全自动生化分析仪测定血清胆固醇(TC)、甘油三脂(TG)和高密度脂蛋白(HDL-C)水平。结果饮用某天然矿泉水第30 d,高脂模型实验组大鼠血清中TG水平与对照组相比显著降低,差异显著(P0.05),TC和HDL-C水平无显著性差异;第40 d时高脂模型实验组大鼠血清中TG水平与对照组相比极显著降低,差异极显著(P0.01),同时统计学分析表明该天然矿泉水虽未降低TC水平和提高HDL-C水平,但饮用该天然矿泉水后雌性大鼠TC水平有下降的趋势并且HDL-C水平有升高的趋势,而自来水组雌性大鼠TC水平较第30 d时呈现增加的趋势。结论某天然矿泉水具有改善实验性雌性高脂大鼠血脂的趋势。     

Plasma triglyceride and β-hydroxybutyric acid levels in red-sided garter snakes (Thamnophis sirtalis parietalis) at emergence from hibernation

Measurement of plasma levels of triglycerides and -hydroxybutyric acid in females and males of the red-sided garter snake (Thamnophis sirtalis parietalis) suggest that the former may provide a useful physiological marker of condition. Levels of triglycerides at emergence from hibernation during a month of natural aphagia were significantly greater in females than in males and she-males, a subset of the male population that mimics females. Higher levels of triglycerides in the females may be attributed to their greater body mass per unit length, which was correlated with the level of triglycerides. Plasma triglyceride levels declined in females within one month of emergence, at the onset of feeding, and were unrelated to mating.     

温胆汤对高脂血症大鼠及小鼠体内脂质代谢调节机理研究

目的 :探求温胆汤对实验动物体内脂质代谢调节作用的机理。方法 :采用腹腔注射蛋黄乳剂的方法建立急性高脂血症小鼠模型 ,观察温胆汤对急性高脂血症成年小鼠粪便脂质含量、血清总胆固醇 (TC)、血清总甘油三酯 (TG)、低密度胆固醇 (LDL c)含量、血清丙二醛 (MDA)含量、血清超氧化物歧化酶 (SOD)活性、肝脏总脂解酶(LA)活性、脂蛋白脂肪酶 (LPL)活性和肝脂酶 (HL)活性的影响 ;建立大鼠高脂血症模型 ,观察温胆汤对大鼠血脂(TC、TG)水平、总脂解酶 (LA)、脂蛋白脂酶 (LPL)和肝脂酶 (HL)活性 ,以及肝脏低密度脂蛋白受体 (LDLR)基因表达的影响。结果 :温胆汤可降低小鼠粪便脂质含量 ,显著降低急性高脂血症小鼠血清TC、TG、LDL c含量 (P <0 .0 5 ) ,温胆汤还可提高血清SOD活性 ,降低MDA含量 ,达到降低体内脂质过氧化程度的目的。同时 ,温胆汤可提高肝脏脂蛋白脂肪酶 (LPL)活性和肝脏总脂解酶 (LA) ,但对肝脂酶 (HL)活性无明显影响。在针对高脂血症大鼠的实验研究中发现 ,温胆汤能够显著抑制大鼠血清总胆固醇 (TC)、血清总甘油三酯 (TG)浓度 ,提高脂蛋白脂酶(LPL)和总脂解酶 (LA)活性 ,但对肝脂酶 (HL)活性无明显影响 ;逆转录聚合酶链反应 (RT PCR)实验显示高脂饲料能显著降低大鼠肝脏LDLRmRNA水平 ,温胆汤能显?