Regulation of cell adhesion by PP2A and SV40 small tumor antigen: An important link to cell transformation

The serine/threonine protein phosphatase 2A (PP2A) represents a large family of highly conserved heterotrimeric enzymes. Their critical importance in cell homeostasis is underlined by the fact that they are targets of natural toxins like the tumor promoter okadaic acid, and of simian virus 40 small tumor antigen (SV40 small t), a viral protein known to promote cell transformation. Furthermore, mutated or lower expression levels of PP2A subunits have been found in certain cancers. One major known event in PP2A-dependent cell transformation is the alteration of key signaling pathways that control cell growth and survival. In this review, we focus on how PP2A enzymes also affect cell adhesion and cytoskeletal dynamics, the disruption of which is linked to loss of cell polarity, increased cell motility and invasiveness. We also examine how those various pathways participate in the transforming activity of SV40 small t. Received 29 June 2006; received after revision 3 August 2006; accepted 20 September 2006     

Sramek公式及修正式计算每搏量与导纳法的比较

本文应用阻抗—导纳式心输出量机对40名正常成年人(男、女各半)进行每搏量(SV)的测定,并把Sramek公式及Sramek修正式和导纳法3种不同方法测得的SV进行比较。结果表明,应用Sramek公式和Sramek修正式测得的SV均大于标准对照值,而导纳法的SV值在标准对照值范围内。提示导纳法测得的SV值可能更为可靠。     

金融波动的平方根随机自回归波动模型

讨论了SR-SARV模型的时间聚合性和同期聚合性,比较了波动模型之间的关系,指出了SR-SARV模型研究的意义,并给出其参数估计方法,对上证指数进行了实证研究。     

基于SV-Copula的欧盟碳配额现货和期货价格相依性研究

碳配额现货和期货价格的相依性对投资者进行套期保值和投机套利均具有重要意义.本文采用SV (stochastic volatility)模型研究了欧盟碳配额现货和期货价格的波动特征,继而用Copula函数分析了两者之间的相依结构,结果发现:EU ETS (European Union Emissions Trading Scheme)第二阶段和第三阶段的碳现货与碳期货价格都存在显著的波动持续性和杠杆效应,且第三阶段碳现货和碳期货价格的波动风险均大于第二阶段;碳现货和碳期货价格之间存在高度相依性,且第三阶段碳现期货价格尾部相依性更强;两阶段中两者的尾部相依性呈现为对称且厚尾.     

慢病毒载体介导SV40LT致人脐静脉内皮细胞永生化

为成功分离与鉴定人原代脐静脉内皮细胞,用猿猴病毒40大T抗原(SV40LT)异位表达建立永生化人脐静脉内皮细胞系。将含SV40LT cDNA片段的慢病毒载体,转染人原代脐静脉内皮细胞,连续传代培养。通过形态、细胞免疫组织化学、RT-PCR及管状成形试验进行原代及转染后细胞形态学和功能学鉴定及检测SV40大T抗原表达。结果SV40LT转染后的人脐静脉内皮细胞为扁平多角形或短梭状,呈单层铺路石状镶嵌排列。特异性表达Ⅷ因子、KDR、SV40LT表达,并具有管状成型能力。说明成功分离与鉴定永生化的脐静脉内皮细胞系,为后续血管靶向治疗奠定了基础。     

沪深股市的波动性分析——基于t分布下GARCH和SV模型的比较

构建基于N分布和t分布下的GARCH(1,1)和SV模型,并通过实证分析探讨了上证指数和深证成指收益序列的波动性.分析结果表明,GARCH(1,1)类模型和SV类模型能较好地拟合沪深股市收益率的波动,并指出我国股市存在较强的波动持续性;而基于t分布的各模型能有效地刻画股市的厚尾性;此外,通过计算VaR值,说明深市比沪市的风险更大,且SV类模型能更准确地反映收益率的风险特性.     

基于MCMC方法的两类波动模型的应用比较

采用中国股市数据，运用基于Gibbs抽样的MCMC方法对ARCH—GARCH模型族与SV模型族进行了比较分析．实证结果显示，无论是从收益率序列峰度系数的描述看，还是从平方收益率序列自相关函数的描述来看，SV模型族都优于GARCH模型族；进一步，基于t分布的模型模拟效果总是优于基于正态分布的模型，看出股市收益率序列并不服从正态分布，     

SV40 transformed fibroblasts recognize the same 140 kD fibronectin chemotactic fragment as non-transformed cells

Summary SV40 virus-transformed human embryonal fibroblasts show an enhanced chemotactic response to the glycoprotein fibronectin. However, they recognize the same chemotactic active region as non-transformed fibroblasts. The result suggests that an enhancement of chemotaxis by fibroblasts which have been transformed with Simian Virus 40 is due not to the utilization of further chemotactic domains in the molecule, but to an increased sensitivity of the cells to the chemoattractant.     

隧道中高速列车震动所产生的路基动应力集中

针对高速列车产生的震动,基于弹性波的散射理论,采用波函数展开法,研究了隧道中板型路基上的圆孔对SV波的散射和动应力集中,得到了问题的解析解,给出了路基中动应力集中因子的数值解,分析了路基的剪切模量的大小、波数等对动应力集中的影响.通过数值计算分析表明,板型路基的剪切模量的大小、波数等是影响动应力集中的重要因素,为隧道中板式路基的高速列车震动评价和地震评价提供了理论依据.