Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

（BN）n及SiB（n-1）Nn（n=2-11）稳定结构的研究

利用遗传算法及Gastreich提出的经验势函数,研究了（BN）n（n=2-11）和SiBn-1Nn（n=2-11）团簇的可能稳定结构,对能量较低的异构体在HF/STO-3G水平进行优化,得到了（BN）n（n=2-11）和SiBn-1Nn（n=2-11）团簇稳定结构单环及线状结构,并进一步分析了单环的结构特征及相对稳定性。     

日本人的“ラち”、“そと”意识与日语的时态转换

从日本人的“ラち”、“そと”意识角度出发，通过对川端康成、志贺直哉的几部小说进行分析统计，探讨日语在描写过去的事件中，插入“内时态‘る’形”的条件和原因。分析发现当作者为了使作品更生动，或是作者与作品中人物产生“同感”时，或是表达作者的主观思想、评论时，往往发生时态的转换。     

纤维双相钢的组织形成及对性能的影响

研究了纤维双相15Mn2Nb钢组织的形成及对性能的影响.结果表明,纤维双相钢具有优异的强塑性匹配,是一种天然的复合材料.其纤维组织的获取主要取决于合金化和热处理工艺规程,而合金元素Nb阻碍铁素体再结晶是形成纤维组织的关键.     

V2O5和Li2CO3共掺杂对Mg4Nb2O9陶瓷烧结行为及微波介电性能的影响

采用固相法，制备了Mg4Nb2O9（MN）微波介质陶瓷，研究了V2O5和Li2CO3共掺杂对MgaNb2O9陶瓷烧结行为、相结构、显微结构和微波介电性能的影响．结果表明，采用1．5％V2O5和1．5％Li2CO3共掺杂，能够将Mg4Nb2O9（135O℃）陶瓷的烧结温度降至925℃，且有助于Mg4Nb2O9单相的形成．3．0％（V2O5，Li2CO3）共掺杂样品在925℃空气中烧结5h可获得良好的微波介电性能（介电常数为13．7，品质因数为77975GHz）．     

Nb微合金化对低合金高强钢耐海水腐蚀性能的影响

利用室内模拟海水加速腐蚀试验及电化学分析,研究了Nb微合金化对Cu-Cr-Ni-P系低合金高强钢耐海水腐蚀性能的影响。结果表明,含Nb钢与不含Nb钢组织均由铁素体和珠光体构成,但Nb微合金化后钢中珠光体组织减少且晶粒细化明显,其在模拟海水介质中的平均腐蚀速率与不含Nb钢相比,降低了约12%,阳极腐蚀电流密度也有所降低。由此可见,在Cu-Cr-Ni-P系低合金高强钢中加入Nb元素有助于提高其耐海水腐蚀性能。     

清中后期社会历史文化心态的展现——以小说《荡寇志》为例

《荡寇志》是清中后期保守士人面对西潮涌入、传统文化失落的集体性情感反应的产物,小说作者俞万春以捍卫中国传统文化的基本价值为己任,担负起了文化卫道的使命。但残酷的现实却撕碎了他加强君权、帝制,肃清内乱来重振国威的卫道美梦,小说《荡寇志》便展示了这一特定历史时期各种社会变革思潮下的社会历史文化心态。     

Description of rotational properties of the superheavy nucleus ^256,258,260Rf by projected shell model

Band structure of the Z = 104 nucleus 256Rf has been a recent research focus in nuclear physics. We performed projected shell model calculations for this and some other neighboring Rf isotopes. Specifically, we studied rotational properties of these nuclei and showed that variations in dynamic moment of inertia were sensitive to single-particle structures, which may be useful information for locating the anticipated island of stability. Electromagnetic transition properties were also calculated, and measurable quantities were predicted for further experimental test.     

DanHong Injection inhibits the development of primary abdominal aortic aneurysms in apoE knockout mice

Clinical observations indicate that DanHong Injection （DHI） can increase blood flow and reduce various syndromes in patients with cardiovascular disease. How- ever, it still needs to define the function of DHI and the involved mechanisms in details, such as the protective effect on the development of primary abdominal aortic aneurysms （AAAs）. In this study, we determined whether DHI is able to inhibit AAA in apoE knockout （apoE-/-） mice. Thirty apoE-/- male mice on high-fat diet （0.5 % cholesterol, 21% fat） were randomly divided into two groups and received i.p. injection of saline （100 μL/day） and DHI （100 μL/day）, respectively, for 16 weeks. At the end of experiment, we determined the development of atherosclerosis in en face aorta and aneurysms,pathological morphology of arterial wall, and serum lipid levels. We also determined the expression of monocyte chemoattractant protein-1 （MCP-1）, MMP-2, and MMP-9 mRNA in aortic wall using real-time RT-PCR. Our results indicated that high-fat diet induced the development of AAAs in apoE-/- mice, but the induction was totally blocked by DHI （P 〈 0.01）. The result of staining of abdominal aortic cross sections showed that DHI main- tained the collagen content in arterial wall, thereby pre- venting the animals from the development of AAA. Although DHI had little effect on serum total- and LDL- cholesterol levels, it reduced the expression of MCP-1, MMP-2, and MMP-9 mRNA in aortic wall （P 〈 0.01）. Taken together, our study suggests that DHI can inhibit the high-fat diet-induced AAA formation. The inhibitory effects may be related to the maintenance of the collagen content and inhibition of expression of AAA-related genes. Our study may suggest a new application of DHI in clinics.     

(λ,μ)-模糊粗糙子群

本文根据(λ,μ)-模糊正规子群定义了新的同余关系,由此提出了(λ,μ)-模糊粗糙子群和(λ,μ)-模糊粗糙正规子群的概念,并研究了它们的性质.