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Izaurralde E 《Cellular and molecular life sciences : CMLS》2001,58(8):1105-1112
The distinguishing feature of eukaryotic cells is the segregation of RNA biogenesis and DNA replication in the nucleus, separate
from the cytoplasmic machinery for protein synthesis. As a consequence, messenger RNAs (mRNAs) and all cytoplasmic RNAs from
nuclear origin need to be transported from their site of synthesis in the nucleus to their final cytoplasmic destination.
Nuclear export occurs through nuclear pore complexes (NPCs) and is mediated by saturable transport receptors, which shuttle
between the nucleus and cytoplasm. The past years have seen great progress in the characterization of the mRNA export pathway
and the identification of proteins involved in this process. A novel family of nuclear export receptors (the NXF family),
distinct from the well-characterized family of importin β-like proteins, has been implicated in the export of mRNA to the cytoplasm.
Received 23 January 2001; received after revision 12 April 2001; accepted 12 April 2001 相似文献
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