Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

（BN）n及SiB（n-1）Nn（n=2-11）稳定结构的研究

利用遗传算法及Gastreich提出的经验势函数,研究了（BN）n（n=2-11）和SiBn-1Nn（n=2-11）团簇的可能稳定结构,对能量较低的异构体在HF/STO-3G水平进行优化,得到了（BN）n（n=2-11）和SiBn-1Nn（n=2-11）团簇稳定结构单环及线状结构,并进一步分析了单环的结构特征及相对稳定性。     

古交矿区煤的热解脱硫试验

文章详细介绍了对古交矿区8号煤进行不同升温速度和不同终温条件下的硫试验。     

日本人的“ラち”、“そと”意识与日语的时态转换

从日本人的“ラち”、“そと”意识角度出发，通过对川端康成、志贺直哉的几部小说进行分析统计，探讨日语在描写过去的事件中，插入“内时态‘る’形”的条件和原因。分析发现当作者为了使作品更生动，或是作者与作品中人物产生“同感”时，或是表达作者的主观思想、评论时，往往发生时态的转换。     

平果岩溶堆积铝土矿空间分布特征及成因探讨——以教美矿区为例

以平果堆积铝土矿教美矿区为例,对矿区堆积铝土矿的空间分布特征及成因进行了探析,提出了岩溶堆积铝土矿的堆积序列和分布规律。     

霍州矿区断层构造的分形特征

霍州矿区断层构造的分形特征与渭河盆地东区基本相同，都形成于张扭性的动力学环境；矿区内各井田的断层分维值以白龙井田最高，团柏井田最低；分维值的大小体现断层构造的复杂程度。     

金融时间序列的数据挖掘技术与经典统计模型的比较

基于对时间序列的数据挖掘思想与经典建模法的基本思路分析和比较，总结各自的优缺点，并阐述二者是在本质上不同的两类重要的时间序列分析法。     

矿产资源型企业社会责任评价研究——以兖州煤业为例

近年来企业社会责任成为了全球热议的话题,学术界对于企业是否应当履行社会责任已经基本达成共识.矿产资源型企业不仅在经济发展中占据非常重要的地位,且易对资源环境协调发展产生牵制作用.我国矿产资源型企业社会责任评价研究起步较晚,还未形成具有普适性的评价指标体系.研究从契约型利益相关者和公众型利益相关者两个视角出发,运用SMART原则筛选出22项指标,结合层次分析法构建了矿产资源型企业社会责任评价体系,以兖州煤业年报数据作为样本进行实证分析,发现其企业社会责任履行情况呈W型变化.并进一步提出政府作为利益相关者、政策制定者和监管者,对于企业履行社会责任具有主推作用,且其他利益相关者在矿产资源开发利用中较易受到侵害,对他们的充分调动有助于形成合力,促进矿产资源型企业履行社会责任.     

清中后期社会历史文化心态的展现——以小说《荡寇志》为例

《荡寇志》是清中后期保守士人面对西潮涌入、传统文化失落的集体性情感反应的产物,小说作者俞万春以捍卫中国传统文化的基本价值为己任,担负起了文化卫道的使命。但残酷的现实却撕碎了他加强君权、帝制,肃清内乱来重振国威的卫道美梦,小说《荡寇志》便展示了这一特定历史时期各种社会变革思潮下的社会历史文化心态。     

Description of rotational properties of the superheavy nucleus ^256,258,260Rf by projected shell model

Band structure of the Z = 104 nucleus 256Rf has been a recent research focus in nuclear physics. We performed projected shell model calculations for this and some other neighboring Rf isotopes. Specifically, we studied rotational properties of these nuclei and showed that variations in dynamic moment of inertia were sensitive to single-particle structures, which may be useful information for locating the anticipated island of stability. Electromagnetic transition properties were also calculated, and measurable quantities were predicted for further experimental test.