Interactional expertise through the looking glass: a peek at mirror neurons

Interactional expertise is here to stay. Undoubtedly, in some sense of the word, one can attain a linguistic expert level within a field without full scale practical immersion. In the context of the idea of embodied cognition, the claim is provocative. How can an interactional expert acquire full linguistic competence without the simultaneous bodily engagement and real life interaction needed to get the language right? How can one understand the concept of hammering if one has never seen a hammer or felt the weight of the iron head on a fragile thumb? Here I will explore a strange and second-hand way in which bodily engagement could have an impact on our linguistic abilities; this is via the so called mirror neuron system. Since the mirror neuron system blurs the distinction between first and third person activity it can help us understand some of the enigmatic aspects of interactional expertise and pose further questions for research.     

They give you the keys and say ‘drive it!’ Managers, referred expertise, and other expertises

On the face of it, the directors of new large scientific projects have an impossible task. They have to make technical decisions about sciences in which they have never made a research contribution—sciences in which they have no contributory expertise. Furthermore, these decisions must be accepted and respected by the scientists who are making research contributions. The problem is discussed in two interviews conducted with two directors of large scientific projects. The paradox is resolved for the managers by their use of interactional and referred expertise. The same analysis might be applicable to management in general. An Appendix, co-authored with Jeff Shrager, compares the notion of referred expertise with contributory expertise.     

SET domain protein lysine methyltransferases: Structure, specificity and catalysis

Site- and state-specific lysine methylation of histones is catalyzed by a family of proteins that contain the evolutionarily conserved SET domain and plays a fundamental role in epigenetic regulation of gene activation and silencing in all eukaryotes. The recently determined three-dimensional structures of the SET domains from chromosomal proteins reveal that the core SET domain structure contains a two-domain architecture, consisting of a conserved anti-parallel β-barrel and a structurally variable insert that surround a unusual knot-like structure that comprises the enzyme active site. These structures of the SET domains, either in the free state or when bound to cofactor S-adenosyl-L-homocysteine and/or histone peptide, mimicking an enzyme/cofactor/substrate complex, further yield the structural insights into the molecular basis of the substrate specificity, methylation multiplicity and the catalytic mechanism of histone lysine methylation. Received 10 June 2006; accepted 22 August 2006     

The evolution of a trading zone: a case study of the turtle excluder device

This paper explores the evolution of a trading zone by organizing the case study of turtle excluder devices within the model proposed by Collins et al. (2007). The case study offers evidence that trading zones do evolve and that the concepts of enforced and fractionated trading zones hold practical utility for describing and defining the complexities of actual exchanges. In this case a trading zone evolved from enforced to fractionated and ultimately diverged into two trading zones. For each step of the evolution I describe the forces that drove these transitions. Finally, I present an adapted trading zone model that is conceptually a better fit for the turtle excluder device case study.     

全球化条件下的大学生价值观教育

全球条件下大学生价值观嬗变已是不争的事实。从大学生价值观由一元向多元价值取向的嬗变,化价值观嬗变,计划经济向市场经济价值观的嬗变三个方面论述变化的情况。有针对性地提出了建构新的价值观教育体系以应对价值观的嬗变。从继承中华民族讲诚信,以人为本,维护民族尊严,维护国格、人格,“天人合一”的优良价值传统,摒弃不正当竞争,只见物不见人,“全盘西化”,污染破坏环境的错误价值取向等方面提出了建构科学价值观的思考和对策。     

Multifunctions of histone H1 proteins

Among various histones, histone H1 proteins have been appreciated for their multiple functions in diverse biological processes. In addition to being a structural protein in chromatin, H1 proteins also play critical roles in cell cycle, gene expression, and development. Recent studies reveal the possible effects of H1 in some diseases, such as cancer and neurodegenerative diseases. Here, we review different variants of HI, the functions, and post translational modifications of ill variants are also discussed.     

北京奥运会会徽的多模态语篇分析

随着人们交流方式的增多，交流过程中出现的社会符号也越来越多。话语分析的范围也逐渐由单一的语言文字文本扩大到包括图像．声音，动画等多模态文本。多模态话语分析吸引了更多学者的关注。本文是在由克瑞斯和勒文提出的视觉语法的基础上，从再现意义，互动意义，构图意义三个方面对2008年北京奥运会会徽进行了多模态话语分析，以期待对读者在进行图像识读时提供帮助。     

可局部修形的四点ternary插值细分算法

基于变参数四点ternary插值细分理论,提出可局部修形的四点ternary插值细分曲线模式,最后推广到可局部修形的张量积细分曲面.