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Recent insights into the role of integrins in cancer metastasis 总被引:11,自引:0,他引:11
P. Clezardin 《Cellular and molecular life sciences : CMLS》1998,54(6):541-548
Integrins have been repeatedly found involved in cancer metastasis. The past two years have seen considerable evolution in
our knowledge on the role of these integrins in tumour cells. This includes the elucidation of different signalling pathways
by which integrins dictate the anchorage-independent growth, survival and motility of tumour cells. Moreover, integrins may
have a more complex role in cancer metastasis as they cooperate with serine proteases and metalloproteases to promote tumour
cell invasion and angiogenesis. Finally, integrins favour tumor cell extravasation. 相似文献
2.
The integrin family of extracellular matrix receptors regulates many aspects of cell life, in particular cell adhesion and migration. These two processes depend on organization of the actin cytoskeleton into adhesive and protrusive organelles in response to extracellular signals. Integrins are important switch points for the spatiotemporal control of actin-based motility in higher eukaryotes. Ligands of integrin cytoplasmic tails are central elements of signalling pathways involving small GTPases as well as protein and lipid kinases in the regulation of Factin crosslinking, actin treadmilling and de novo nucleation of actin filaments. We present an overview of common pathways and discuss recent evidence for their differential use by individual integrin receptors.Received 24 November 2004; received after revision 17 January 2005; accepted 19 January 2005 相似文献
3.
Leukocyte integrins and inflammation 总被引:6,自引:0,他引:6
C. G. Gahmberg L. Valmu S. Fagerholm P. Kotovuori E. Ihanus L. Tian T. Pessa-Morikawa 《Cellular and molecular life sciences : CMLS》1998,54(6):549-555
Leukocyte adhesion is of pivotal functional importance. Without adequate adhesion, T lymphocytes and natural killer cells
are not cytotoxic, B cells cannot develop into antibody secreting plasma cells, leukocytes do not home into inflamed tissues
and myeloid cells are not able to phagocytize or exhibit chemotactic responses. During evolution several leukocyte adhesion
molecules have developed belonging to a few molecular families. Among these, the leukocyte-specific integrins (β
2 integrins, CD11/CD18 molecules) are among the most important. Much progress has taken place during the past few years, and
at present we have a considerable knowledge of their structure and function. Inflammation is critically dependent on integrin
activity, and its regulation forms the topic of this short review. 相似文献
4.
Integrin-mediated signal transduction 总被引:23,自引:0,他引:23
Integrins, expressed on virtually every cell type, are proteins that mediate cellular interactions with components of the
extracellular matrix (ECM) and cell surface integral plasma membrane proteins. In addition, integrins interact with the cytoskeleton
and through this process participate in cell migration, tissue organization, cell growth, haemostasis, inflammation, target
recognition of lymphocytes and the differentiation of many cell types. Signals generated from ligand-integrin interactions
are propagated via the integrin cytoplasmic tails to signal transduction pathways within the cell (outside-in signalling).
Information from within the cell can also be transmitted to the outside via integrin affinity modulation (inside-out signalling).
Protein tyrosine phosphorylation has a central role in integrin-initiated cell signalling, leading to cytoskeletal organization
and focal adhesion formation. This review will examine the current understanding of integrin function, focusing on the intracellular
consequences of integrin-ligand interaction. 相似文献
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