带有临界增长的Kirchhoff方程极小能量变号解的存在性

为了深入研究Kirchhoff方程的性质,讨论了带有Hartree项和临界增长非线性项的Kirchhoff方程极小能量变号解的存在性。利用能量泛函在变号Nehari流形上的下确界C_λ收敛于0,得到空间E紧嵌入L~6(R~3)这一技术性结果。结果表明,利用限制变分方法和定量形变引理获得极小化序列对应的极小值点是该问题的非平凡解。研究方法在理论证明方面得到了良好的结果,对研究其他Kirchhoff方程解的存在性有一定的指导意义。     

刚-柔性桩复合地基设计理论探讨

刚-柔性桩复合地基设计理论的发展明显地落后于工程实践,基于工程实践成果以及计算机仿真分析结果对刚-柔性桩复合地基设计理论进行了研究,根据不同的基础形式对刚-柔性桩复合地基进行分类,分析了不同型式复合地基的适用性,提出了具体的设计步骤,探讨了承载力与变形等相关问题.此外,还提出了刚-柔性桩复合地基优化设计的建议,并通过工程实例对上述设计理论进行验证.     

与时俱进,提升高校党委的工作水平

面对新时期新形势新任务，要与时俱进做好工作．高校党委必须提高认识水平、协调水平、管理水平和创新水平，最终体现为发展水平。     

中西方对青少年异性交往的态度及教育效果比较

对青少年异性交往的态度，中国自古以来比较保守、消极，西方比较开放、积极，我们应该把二者的优点结合起来．把青少年的异性交往引入健康的轨道。     

论社会转型中的德治困境及以德育人

社会转型中道德问题日显突出，以德治国的方略就置于中国这一特殊的历史背景和道德实践之中。我国对社会转型前后的道德特征的比较中，提出既要防止道德的政治化，又要警惕道德的功利化，真正坚持唯物辨证法，全面实施以德育人，只有提升全民族的道德水准，才能真正实现以德治国。     

高中学生的物理成绩的调查与分析

经过两年广泛的调查，对调查结果进行统计，按教育统计学相关分析的计算方法，逐条求出各单元的相应系数。并对量化的部分结果进行了初步分析，指出了高中学生学习物理困难的主要原因，以及进行矫治的初步措施。该调查采集面广，样本大，计算方法科学，量化结果数据可靠，所反映的信息具有一定的代表性，可供中学物理同仁在教学改革中参考。     

Specific anti-tumor effect induced by attenuated Salmonella typhimurium vaccine expressing extracellular region of vascular endothelial growth factor receptor 2

The purposes of this research were to study the stable expression of exogenous gene encoding therapeutic protein in attenuated Salmonella typhimurium, observe the metabolism of oral gene vaccine carried by attenuated Salmonella typhimurium in BALB/c mouse, and investigate the feasibility of prevention and treatment of tumors by the recombinant bacteria. Recombinant plasmid pcDNA3.1 VEGFR2(n1-7) was transformed into competent attenuated Salmonella typhimurium SL3261 to develop oral DNA vaccine SL3261-pcDNA3.1 VEGFR2(n1-7). To observe whether the exogenous gene can be expressed in the recombinant bacteria, PCR was performed to amplify the CMV promoter of the eukaryotic expression vector as the proof of stable expression of exogenous protein; transmission elec- tron microscopy (TEM) was applied to observe the morphology of the recombinant bacteria to confirm that the exogenous gene has no impact on the growth of the bacteria, and then BALB/c mice were immunized with the gene vaccine. After inoculation of the gene vaccine, the recombinant bacteria SL3261 could be detected in the tissues such as small intestine, colon, liver and spleen. And then, mice in each group were challenged with tumor cells. The results of animal experiment showed that tumor growth of the mice in experimental group was inhibited and survival time of immunized mice was prolonged compared with control groups. A higher lymphocyte infiltration in tumors from animals treated with DNA vaccine was observed. Immunohistochemical analysis of tumor samples revealed an en- hanced accumulation of CD8 cytotoxic T lymphocytes, as well as an increase in CD4 cells in the tumors of animals treated with the oral gene vaccine compared to tumors from control group mice. Ultrastructure of the tumor tissue showed that tumor cells in the samples of the immunized mice were well-differentiated. Our research confirmed that the exogenous gene can be stably expressed in the attenuated Salmonella typhimurium and has no impact on the growth of the recombinant bacteria; the exogenous gene can de delivered to the host by attenuated Salmonella typhimurium to produce anti-tumor effect with no obvious cytotoxity to the host. In this study, it is established that attenuated Salmonella typhimurium could be used as a vector for oral gene vaccine, and our study provided a theoretical basis for the body distribution and the metabolism of the recombinant bacteria. This strategy may provide a simple, safe and effective way for the prevention and treatment of tumors.     

大直径长钻孔桩孔底压浆技术的探讨

分析了某工程桩底缺陷形成的原因,介绍了桩底补强过程中的造孔、清淤、压浆及验证的具体做法。     

均匀带电圆环的电势

从电势的一般概念出发得出均匀带电圆环的公式，并讨论在极限情况下约化为均匀带电细圆环的电势公式。