Nerve-mediated action of forskolin on guinea pig ileal mucosa

Summary The effects of forskolin on myenteric neuronal activity and mucosal function were examined in guinea pig ileum. Forskolin increased the excitability of myenteric neurons, and increased mucosal chloride secretion by stimulating enteric neurons as well as by acting directly on enterocytes.Acknowledgment. The authors thank E. Martens, S. Bowen for technical assistance and N. Schaad for secretarial assistance. This work was supported by National Institutes of Health Grants, F32-AM07301, K-104-AM1004, RO1-AM29699, RO1-AM26742 and an Eloise Gerry Fellowship.