d—BCS^—的制取及对某些钴（Ⅲ）络合物的拆分与识别研究

研究了用△-(-)_D-[Co(en)_2(C_2O_4]~+及∧-(+)_D-[Co(en)_2(C_2O_4)]~+拆分NH_4(dL-BCS)的方法,制得了两种难溶非对映异构体盐的单晶:△-(-)_D-[Co(en)_2(C_2O_4)](d-BCS).3.5H_2O(Ⅰ)与∧-(+)_D-[Co(en)_2(C_2O_4)](L-BCS)2.5H_2O(Ⅱ)。探讨了晶体中可能的识别模式,用自制的 NH_4(d-BCS)简便地拆分了Cis-[Co(en)_2(NO_2)_2]~+;部分拆分了[(Co(en)_2(gly)]~(2+);讨论了 d-BCS~-对络合物的识别作用。     

噁唑硼烷催化酮砜不对称还原的半经验方法研究

对噁唑硼烷催化前手性酮砜不对称还原反应进行了半经验MNDO研究.结果表明,该不对称还原反应是放热的,反应的手性控制步骤是氢从BH3向酮羰基碳的转移,氢转移反应通过一个六元环过渡态完成,是不可逆的.     

（R）—苯基甘氨醇的一些化学有择反应

讨论了（Ｒ）－苯基甘氨醇的一些化学选择性反应，所制得的手性合物在不对称合成中具有应用价值。     

噻唑烷并手性恶唑硼烷催化剂结构和性质的量子化学研究

采用量子化学从头计算方法研究了噻唑烷并手性恶唑烷催化剂及其硼烷加合物的结构和性质，选用Hartree-Fock方法从6-31g基组下进行了全优化计算，并计算了催化剂其加合物的红外振动光谱，催化剂具有扭曲的椅式构型，与硼烷在N原子处配位形成加合物，反应是放热的，加合物的形成，一方面使得催化剂上B原子所带正电荷增加，有利于与酮羰基氧的配位反应进行；另一方面使得BH3中B-H键被削弱，有利于后续反应中H从BH-3到酮羰基碳的转移，从而增强了催化反应的活性。     

含手性轴化合物的构型标定法

根据多年的教学经验以及对手性轴化合物的立体化学方面的研究提出了一种对含手性轴化合物的 R、S构型标定的简易方法。     

同轴回旋波导的高次模分析

本文研究了同轴回旋波导(coaxial chirowaveguide)中高次模的传播特性。同轴回旋波导是由同轴波导中填充回旋媒质(chiral media)而形成的。文中首先给出了回旋波导的一般理论,然后推导得到了计算同轴回旋波导中高次模传播常数的特性方程,最后给出了若干数值结果。     

固—液手性相转移催化烷基化——Ⅰ合成(-)—2—甲酰乙氧基—2—壬烷基环戊酮

在相转移催化条件下,以己二酸为原料合成了(一) 2 甲酰乙氧基 2 壬烷基环戊酮。     

Chiral ligand-protected gold nanoclusters: Considering the optical activity from a viewpoint of ligand dissymmetric field

Chirality is a geometric property of a physical, chemical, or biological object, which is not superimposable on its mirror image. Its significant presence has led to a strong demand in the development of chiral drugs, sensors, catalysts, and photofunctional materials. In recent years, chirality of nanoscale organic/inorganic hybrids has received tremendous attention owing to potential applications in chiral nanotechnology. In particular, with the recent progress in the syntheses and characterizations of atomically precise gold nanoclusters protected by achiral thiolates, atomic level origins of their chirality have been unveiled. On the other hand, chirality or optical activity in metal nanoclusters can also be introduced via the surface chiral ligands, which should be universal for the nanosystems. This tutorial review presents some optically-active metal (gold) nanoclusters protected by chiral thiolates or phosphines, and their chiroptical (or circular dichroism; CD) properties are discussed mostly from a viewpoint of the ligand dissymmetric field scheme. The examples are the gold nanoclusters protected by (R)-/(S)-2-phenylpropane-1-thiol, (R)-/(S)-mercaptosuccinic acid, phenylboronate-D/L-fructose complexes, phosphine sulfonate-ephedrinium ion pairs, or glutathione. Some methodologies for versatile asymmetric transformation and chiroptical controls of the nanocluster compounds are also described. In the dissymmetric field model as the origin of optical activity, the chiroptical responses of the gold nanoclusters are strongly associated with coupled oscillator and/or CD stealing mechanisms based on the concept of induced CD (ICD) derived from a perturbation theory, so on this basis, some characteristic features of the observed CD responses of chiral ligand-protected gold nanoclusters are presented in detail. We believe that various kinds of origins of chirality found in ligand-protected gold nanoclusters may provide models for understanding those of many related nanomaterials.     

手性金属试剂催化的不对称合成及其工业应用

研究报告了不同类型的不对称催化反应,介绍了它们在医药、农药、香精、食品添加剂等方面的实际应用。     

HPLC法测定兔血浆中SFZ-47对映异构体浓度

建立家兔血浆中新抗炎镇痛剂 SFZ- 47[(± ) - 3H - 1 ,2 -二氢 - 2 - ( 4 -甲基苯胺基 ) -甲基 - 1 -吡咯里嗪酮 ]对映异构体浓度测定的高效液相色谱 ( HPL C)测定法 .采用反相 HPLC测定服药后血浆中 (± ) - SFZ- 47,同时收集其流出组分 .经浓缩后 ,再用 Chiral- AGP手性色谱柱进行对映异构体的直接分离 ,达到了良好的分离效果 .实验表明 ,动物体内药物动力学过程具有明显的立体选择性