含裂纹压电材料的Cell-Based光滑有限元法

裂纹缺陷限制了压电材料更广泛的应用和相关器件性能的进一步提升.为提高求解压电材料断裂参数的精度和效率,将复势函数法和Cell-based光滑有限元法引入到含裂纹平面压电材料问题中,提出了含裂纹压电材料的Cell-based光滑有限元法.以含中心裂纹压电平板的问题为例,对不同材料、裂纹长度、网格和光滑子元数下的正则强度因子进行了讨论,并与FEM作了对比,数值算例结果表明,Cell-based光滑有限元法改善了有限元法刚度"偏硬"的缺点,具有高精度、高效率的优点.     

力电湿多物理场耦合Cell-Based光滑有限元法研究

为了解决压电结构在实际工程应用中受到空气湿度影响的问题，基于压电材料的本构方程、几何方程和平衡方程提出了力电湿多物理场耦合Cell-based光滑有限元模型.建立了一种新型压电俘能器，并对其简化模型的静力学性能进行求解，对比了不同湿度变化对结构性能的影响.与有限元法的计算结果对比，Cell-based光滑有限元法采用较少的网格就能够达到与有限元法采用较多的网格相同的精度，验证了本方法的正确性和有效性.研究发现，较小的湿度变化给结构的广义位移带来了较大的影响.压电结构在潮湿环境下的性能研究为复合材料产品化过程提供了理论依据.     

Development of a functional cell-based HTS assay for identification of NKCC1-negative modulators

Na–K–Cl cotransporter 1(NKCC1) cotransports Na+, K+, and Cl-ions across the plasma membrane into cells. Accumulation of Cl-ions in dorsal root ganglion neurons induces depolarizing GABAA receptors, which mediate presynaptic inhibition and filtration of sensory noise. The activity of the Na–K–Cl cotransporter is modulated by high-dose loop diuretics, such as furosemide and bumetanide. To identify NKCC1 modulators, we developed a functional cell-based assay feasible for highthroughput screening(HTS), in which the activity of NKCC1 was detected by a BTC-AM dye-based thallium transportation assay. We demonstrated that the influx of Tl?was mediated by NKCC1, which required the existence of Cl-ions and could be inhibited by bumetanide and furosemide. Our results demonstrated that the assay was stable, reproducible, and suitable for HTS of negative modulators for NKCC1.