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J. N. D. Wurpel 《Cellular and molecular life sciences : CMLS》1994,50(5):475-478
This study investigates the effect of the gamma-aminobutyric acid (GABAB) agonist, baclofen, on amygdala kindling in adult rats. Baclofen has been reported to be anticonvulsant in a variety of seizure models and prevents kindling in immature rats. These experiments describe the effects of baclofen (2, 5 and 10 mg/kg, i.p.) on the afterdischarge threshold and kindling rate. Baclofen, 10 mg/kg, significantly increased the afterdischarge threshold in the amygdala. Baclofen at 5 and 10 mg/kg, retarded the rate of kindling as measured by the number of stimuli required to advance to subsequent seizure stages. These results suggest that baclofen may decrease the local excitability of the amygdala and retard the rate of seizure spread (or generalization) throughout the brain. Baclofen, acting at GABAB receptors exerts an anticonvulsant effect on amygdala kindling in these experiments. 相似文献
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周雪瑞 《四川师范大学学报(自然科学版)》2001,(2)
采用放射配体受体结合分析法 ,研究了孕烯醇酮 (Pe)和孕烯醇酮硫酸盐 (Pes)对小鼠不同脑区3H GABA与GABAB 受体结合的影响 .结果显示 ,Pe对小鼠下丘脑、大脑皮层、海马、小脑GABAB 受体的结合均有抑制效应 ,且能被GABAB 受体激动剂巴氯芬 (Bac)所阻断并翻转 .Pes对大脑皮层、海马、小脑GABAB 受体的结合有抑制作用 ,而对下丘脑则有促进作用 .Bac能阻断Pes的抑制作用 (海马除外 ) ,加强Pes的促进作用 .实验结果提示 ,Pe ,Pes对各脑区GABAB 受体的结合具有一定的影响作用 ,且多为抑制效应 相似文献
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