排序方式: 共有17条查询结果,搜索用时 15 毫秒
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Jinwon Lim Hyo-Jung Lee Bonglee Kim Jeong-Un Choi Yoeok Shin Eun Jung Sohn Sung-Hoon Kim 《科学通报(英文版)》2014,59(25):3127-3133
Though Hongbaekjeong(HBJ),a hebal mixture of three medicinal plants,has been traditionally used for arthritis and muscular pain,its scientific evidence still remains unclear.Thus,in the present study,analgesic and anti-inflammatory mechanism of HBJ was evaluated in vitro and in vivo.HBJ significantly reduced NO production and prostaglandin E2(PGE2)release and also attenuated the expression of cyclooxygenase 2(COX-2)in lipopolysaccharides(LPS)and interferon(IFN)-c treated RAW 264.7 cells.Furthermore,HBJ abrogated the production of proinflammatory cytokines such as interleukin(IL)1b,IL-6,IL-8 and monocyte chemoattractant protein-1(MCP-1)in LPS and IFN-c treated RAW 264.7 cells.In addition,HBJ significantly decreased the number of writhing syndrome induced by acetic acid,and also increased latency in hot-plate method and tail flick test in mice.Consistently,HBJ significantly reduced the edema volume in the hind paw of the rats with arthritis induced by Freund’s complete adjuvant(FCA)compared to untreated control.Collectively,our findings demonstrate the antiinflammatory and analgesic potential of HBJ via inhibition of proinflammatory cytokines and PGE2 release for treatment of arthritis and muscular pain. 相似文献
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研究复方威茯的急性毒性作用,并观察其抗炎镇痛作用。以最大给药量方法进行急性毒性实验,观察小鼠一般情况等,14 d后处死解剖,观察小鼠主要脏器组织病变情况。以二甲苯致小鼠耳廓肿胀、醋酸致小鼠腹腔毛细血管通透性增加,实验观察复方威茯抗炎作用。以冰醋酸致小鼠扭体、热板致小鼠疼痛探讨复方威茯镇痛作用。结果在急性毒性实验中,未见小鼠有中毒症状或死亡,外观表现未见异常,解剖后未见脏器异常;复方威茯可明显抑制二甲苯所致小鼠耳廓肿胀度和醋酸致腹腔毛细血管通透性的增高(P0.05或P0.01),可明显减少醋酸致小鼠扭体反应次数(P0.01),可提高热板致小鼠疼痛的痛阈值(P0.05或P0.01)。说明复方威茯无明显的急性毒性作用,有明显的抗炎镇痛作用。 相似文献
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背景:鸡屎藤具有明确的镇痛作用,鸡屎藤苷酸与鸡屎藤苷酸甲酯是()。目的:考察鸡屎藤苷酸(Paederosidic Acid)与鸡屎藤苷酸甲酯(Paederosidic Acid Methyl Ester)二聚体不同浓度下的镇痛作用,并初步探讨其作用机制。方法:采用ICR小鼠,以小鼠福尔马林实验进行镇痛作用评价,以热板实验确定镇痛机制。结果:福尔马林实验结果显示,鸡屎藤苷酸与鸡屎藤苷酸甲酯二聚体有镇痛效果。利用热板实验,确定鸡屎藤苷酸与鸡屎藤苷酸甲酯二聚体为中枢镇痛作用,40mg/kg是镇痛的最大效应浓度。结论:鸡屎藤苷酸与鸡屎藤苷酸甲酯二聚体有中枢镇痛作用。 相似文献
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J. L. Torres I. Haro G. Valencia F. Reig J. M. García-Antón 《Cellular and molecular life sciences : CMLS》1989,45(6):574-576
Summary A new series of O-glycosyl enkephalins has been prepared, following a convergent strategy, with high chemical yields. The galactosyl analogue,O
1.5-(-D-galactopyranosyl) [DMet2, Hyp5] enkephalin amide proved to be one of the most potent in vivo opioid agonists synthesized up to now. 相似文献
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天南星及炮制品镇痛作用与毒性相关性的实验观察 总被引:1,自引:0,他引:1
目的:实验观察天南星及炮制品镇痛与毒性的相关性,寻求镇痛成分提取的可能性。方法:热板法比较镇痛效果,致死时间比较毒性。结果:给药0.5h痛阈提高百分率,生药及民制品均在85%以上,生品1.5h后便有20%死亡,用民制品次日死亡,其它制品痛阈提高百分率在70%以下,3d后死亡。结论:某毒性成分具有镇痛作用,水溶性差,提取可能。 相似文献
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方继光 《安庆师范学院学报(自然科学版)》2002,8(4):11-13
设f(z)=∑∞n=1anfn(z)收敛半径R=1及φ(z)=∑∞n=1ann!zn,则可用函数:F(z)=∫∞0e-1Φ(tz)dt对f(z)进行解析延拓到区域G,G的边界为所有在f(z)的奇点与单位圆相切的直线。 相似文献
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目的:初步研究嘎古拉-4味汤散的镇痛、镇静、抗炎作用.方法:用热板法和扭体法实验,观察其镇痛作用;用戊巴比妥钠对小鼠睡眠时间的影响实验,观察其镇静作用;对二甲苯致小鼠耳廓肿胀炎症模型的影响实验.观察其抗炎作用.结果:嘎古拉-4味汤散对醋酸所致小鼠扭体反应和热板法所致疼痛刺激有明显的镇痛、镇静作用;对二甲苯所致小鼠耳廓肿胀炎症没有明显的预防和治疗作用.结论:初步研究结果表明,嘎古拉-4味汤散具有明显的镇痛、镇静作用,但没有显著的抗炎作用. 相似文献
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Tahsin COLAK ;Tamer AKCA ;Ozgur TURKMENOGLU ;Hakan CANBAZ ;Bora USTUNSOY ;Arzu KANIK ;Suha AYDIN 《浙江大学学报(自然科学英文版)》2008,(4):319-323
Objective: This prospective randomized clinical trial was conducted to evaluate the necessity of drainage after total thyroidectomy or lobectomy for benign thyroidal disorders. Methods: A total of 116 patients who underwent total thyroidectomy or lobectomy for benign thyroidal disorders were randomly allocated to be drained or not. Operative and postoperative outcomes including operating time, postoperative pain assessed by visual analogue scale (VAS), total amount of intramuscular analgesic administration, hospital stay, complications, necessity for re-operation and satisfaction of patients were all assessed. Results: The mean operating time was similar between two groups (the drained and non-drained groups). The mean VAS score was found to be significantly low in the non-drained group patients in postoperative day (POD) 0 and POD 1. The mean amount of intramuscular analgesic requirement was significantly less in the non-drained group. One case of hematoma, two cases ofseroma and three cases of transient hypoparathyroidism occurred in the non-drained group, whereas one case of hematoma, two cases of seroma, two cases of wound infections and two cases of transient hypoparathyroidism occurred in the drained group. No patient needed re-operation for any complication. The mean hospital stay was significantly shorter and the satisfaction of patients was superior in the non-drained group. Conclusion: These findings suggest that postoperative complications cannot be prevented by using drains after total thyroidectomy or lobectomy for benign thyroid disorders. Furthermore, the use of drains may increase postoperative pain and the analgesic requirement, and prolong the hospital stay. In the light of these findings, the routine use of drains might not be necessary after thyroid surgery for benign disorders. 相似文献
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