Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

测量嗅觉诊断病症的"临床鼻"

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电信网络系统的远离平衡态特性分析

远离平衡态是电信网络系统有序演化的必要条件,本文从多样性和非均匀性2个方面对电信网络系统的远离平衡态特性进行了分析,从而揭示了电信网络远离平衡态特性和系统有序演化之间的内在逻辑。     

经鼻滴注氟马西尼在小儿门诊手术麻醉后催醒作用的观察

目的观察经鼻滴注氟马西尼对小儿门诊手术麻醉后的催醒作用。方法38例ASAⅠ级的小儿行门诊小手术后随机分为两组,一组经鼻滴注氟马西尼40μg/kg(用药组),另一组不用药(对照组)。结果用药组的麻醉清醒显著短于对照组(P<0.05)。结论40μg/kg氟马西尼用于小儿手术麻醉后,清醒时间可明显缩短。     

人工嗅觉系统在卷烟内在质量客观评定中的应用展望

概述了人工嗅觉系统的研究历史与应用现状．详细介绍了人工嗅觉系统的基本原理，阐述了基于神经网络的人工嗅觉系统在卷烟内在质量评定中的广阔应用前景．     

浙江乐清方言音系再探

乐清方言的声母有29个,具备了吴语方言的一个重要特征,即浊声母和清声母的对立。韵母30个,没有入声韵和鼻化韵。声调有8个,入声不是短促调,已变为舒声,是先降后升的曲折调。     

牛皮蝇驱避剂的固化及其挂饰

将牛皮蝇驱避剂(SM2H）辅以固化材料混合成型，制成牛皮蝇缓释驱避块，这样即延长驱避药物的有效使用期，又使其成型，方便更换、回收和处理，制作一款可将牛皮蝇缓释驱避块按放在其中并可佩带在牛体上的挂饰，如牛项圈、牛耳环等，在夏季将其佩带在牛体上，让药力缓慢释放达3-4个月，其散发的气味能驱赶牛皮蝇离开牛体，从而阻断牛皮蝇在牛体上产卵，破坏其生活史，达到防治牛皮蝇蛆病的目的。     

醉酒的狐狸和酒醉的猎人(连载)

正七、小狐狸找爷爷天亮了,今天的天阴沉沉的,下着清雪。但风却很大,裹着雪粒,卷着地上的积雪,摇晃着光秃秃的树枝,鬼哭狼嚎般地在森林里叫着。惨白的晨光照进了狐狸洞里,洞里的小狐狸们相继睁开眼睛,昨天白天等了一天,外加昨夜一晚上,却还是没有等回它们的狐仙爷爷。小狐狸们彻底绝望了。它们终于忍不住一起痛哭起来,因为它们都这样想,它们的狐仙爷爷肯定在山下的村子里遭遇到了不幸。