排序方式: 共有10条查询结果,搜索用时 46 毫秒
1
2.
3.
Ren Jin 《中国科学基金(英文版)》2003,11(1):31-34
Toxicological pathology plays a key role in drug safety assessment. To enhance the research level of toxicological pathology, the following studies should be carried out urgently: setting up a standard operation procedure (SOP) for toxicological pathology assessment; emphasizing on immunotoxicology evaluation; adopting a new experiment model of replacement, featuring high speed and reliability; introducing new techniques and new models in toxicological mechanism research; and establishing a new appraisal system to screen innovative drug and rapid and high precision methods for early security assessment, detection and measurement. 相似文献
4.
5.
《科技导报(北京)》2009,(17):29-29
为了及时总结我国动物毒物学及相关领域研究进展,增进同行间的沟通与了解,促进高等学校、科研院所与地方基层单位之间的相互交流与合作,提高动物毒物学的研 相似文献
6.
《科技导报(北京)》2009,(19):84-84
为了及时总结我国动物毒物学及相关领域研究进展,增进同行间的沟通与了解,促进高等学校、科研院所和地方基层单位之间的相互交流与合作,提高动物毒物学的研究和应用水平,经中国畜牧兽医学会批准,由中国畜牧兽医学会动物毒物学分会主办、广东海洋大学承办的"第11次(2009年)全国动物毒物学学术研讨会"将于2009年11月下旬在广东省湛江市召开。 相似文献
7.
Silica nanoparticle is a possible safe carrier for gene therapy 总被引:2,自引:0,他引:2
XUE Zhigang LIANG Desheng LI Yumei LONG Zhigao PAN Qian LIU Xionghao WU Lingqian ZHU Shaihong CAI Fang DAI Heping TANG Baisha XIA Kun XIA Jiahui 《科学通报(英文版)》2005,50(20):2323-2327
In order to develop a safe and effective gene therapy carrier, some toxicological and biodynamical experiments were carried out on silica nanoparticles (SiNPs). First we prepared SiNPs with appropriate portions of cyclohexane, deionized water and ethyl silicate, and then transfected the modified SiNPs and GFP plasmid DNA complex into the HT1080 cells to test the effectiveness of transfection for gene therapy. At the same time, we injected the SiNPs into a number of mice through tail vein. Then we made the mice crossed to evaluate the acute, long-term and reproductive toxicity. In vivo distribution analysis and pathological examination were made on both adult mice and their offspring. SiNPs were uniform and had an average diameter of 40 nm, and the modified SiNPs carried exogenous DNA molecules into target cells and the transferred GFP fusion gene was effectively expressed in the cells. The SiNPs injected via tail vein were widely distributed in almost all of tissues, and the injected mice had the ability to reproduce normally. The in vivo and in vitro results of this study clearly show that SiNPs can be used as a safe and effective carrier for gene transfection and gene therapy. 相似文献
8.
用毒药行凶在历史上曾是种很常见的犯罪手段。因为用毒比较隐蔽,不容易引人注目。而且毒物很难被查出来。只有在极少数的案件中,侦探们才会发现投毒者所使用的毒药。但是现在,投毒者能够心存侥幸逃脱惩罚的时代已经结束了。CSI的毒物学专家运用现代测毒技术,很快就能从某件疑似投毒案中找到线索:是否真有毒物存在?如果有,是什么毒? 相似文献
9.
时间:2012年12月10日影像分析技术早在19世纪末,法国巴黎就有专门给犯人负责拍照的工作部门。负责拍照的那位先生发现通过测量人的面部,可以用来认证罪犯:比如测量人鼻梁的高度、头型可以区分不同的面部特征,碰到两个完全相同的面部特征的机率是非常小。这位先生在没有见到犯罪 相似文献
10.
1