排序方式: 共有14条查询结果,搜索用时 15 毫秒
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邵永胜 《江汉大学学报(自然科学版)》2001,(4)
可切除乳癌手术后 ,病人体内可能存在亚临床的微转移灶。数年后 ,这些亚临床转移灶可能复发 ,最终致死。既往研究表明 ,辅助性应用三苯氧胺可明显改善可切除乳癌的 1 0年生存率 ;但何种病例需用三苯氧胺和用药持续时间仍存争议。许多随机对比试验结果表明三苯氧胺应用 1~2年有效 ,也有报告应用 5年有效。近年 ,一些研究直接比较三苯氧胺应用 5年与 <5年或 >5年的治疗效果 ,但因随访时间不够而无确切结论可用于临床。本研究仅综合分析辅助性应用三苯氧胺与不用三苯氧胺对比的临床试验 ,评价三苯氧胺对可切除乳癌手术后复发率和死亡率的影响… 相似文献
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Study on interleukin-18 gene transfer into human breast cancer cells to prevent tumorigenicity 总被引:5,自引:0,他引:5
To study the effect of interleukin-18 gene transfection on the tumorigenesis of breast cancer cell line Bacp37, human breast cancer cell line Bcap37 were transfected with Lipofectamine and selected by G418. The biological expression of rhIL-18 was tested by RT-PCR and ELISA method; nude mice were injected with Bcap37 cell with or without the hIL-18 gene. The hIL-18 cDNA was successfully integrated into Bcap37 cell; 126.3+/-4.5 pg hIL-18 secreted by one million transduced cells in 24 hours. Nude mice injected with IL-18 gene engineered Bcap37 cell had no tumor growth. These findings indicated that human breast cancer cells were successfully modified by the gene of IL-18 cytokine; the IL-18 gene engineered Bcap37 cells secreted hIL-18 and lost their tumorigenicity. The Bcap37 cells transduced with IL-18 gene may be used as breast cancer vaccine. 相似文献
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李勇 《辽宁大学学报(自然科学版)》2011,(3):241-243
目的:评价乳癌仿根治术后Rotter′s淋巴结阳性率及其临床意义.方法:对184例乳癌仿根治术Rotter′s淋巴结单独病理检查,分析其与肿块大小、腋上组淋巴结、ER及HER-2表达的关系.结果:术后Rotter′s淋巴结共检出48例,阳性20例,检出率和阳性率分别为26.1%和10.9%;阳性组患者在肿块大小,腋上组淋巴结阳性率,ER及HER-2受体表达方面与未检出组,阴性组之间进行比较有明显统计学意义.结论:乳癌患者施行乳癌仿根治术应常规清除Rotter′s淋巴结,术后病理提示Rotter′s淋巴结阳性患者预后较差. 相似文献
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对Ⅱ、Ⅲ期乳腺癌69例综合方法疗效对比分析。全组5年生存率536%,Ⅱ期78%,Ⅲ期472%,Ⅱ期各组(S,S+C,S+R,S+R+C)无显著差别;Ⅲ期各组S142%,S+C33%,S+R473%,S+R+C60%(P<005)说明综合治疗方法对生存率有影响,增加放疗对Ⅲ期尤为显著;加放组淋巴区胸壁3年复发率与未加放组比为1∶2(9/50:7/19),其复发平均时间为318∶135(月),说明加放对局部控制效果的肯定。增加化疗(CMF/CAF/CEF)与未加化疗比生存率有改变,前者为595%(22/37),后者为333%(3/9),而除S组外,增加化疗使S+R+C达60%,S+R473%组无显著性差别(025>P>010)。S+(S+C)与(S+R)+(S+R+C)组5年生存率,前者为368%(7/19),后者为60%(30/50)。 相似文献
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Using indirect immunofluorescence (IIF),an anti-centromere protein CenpG-serum was verified.Western blot of the protein extracts of 31 samples of breast cancer tissues and their normal (not cancerous) tissues a little far away from them in the same individuals showed that,in the majority of the tests(71%),centromere protein CenpG over expressed in breast cancer tissues,And moreover,a kind of protein component whose molecular weight is 43 kd,and which can be recognized by anti-CenpG serum sas found in two of the caner samples,The results suggested that CenpG (together whith it,there may be other relative components),which has been foud and named recently,may be related to cancer,and its differential expressing is probably related to malignant cell proliferation. 相似文献
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区域淋巴结转移与否和转移度是影响乳癌预后的最重要因素,但腋淋巴结组织学检查阴性时或作腋淋巴结组织学检查之前,尚缺乏有价值的预后指标,国内外尚未见P_(53)蛋白和增殖细胞核抗原(PCNA)与腋淋巴结转移数和转移度关系的详细资料报道。本文取27例腋淋巴结资料完整乳癌病例的原发灶蜡块标本作石蜡切片,用SABC法作P_(53)蛋白和PCNA的免疫组化染色并评估其表达与腋淋巴结转移的关系,结果显示P_(53)蛋白表达(阳性或阴性)和PCNA指数均与腋淋巴结转移度和转移数显著相关,P_(53)指数与腋淋巴结转移状况无关。故认为P_(53)蛋白和PCNA表达均为乳癌预后指标,在腋淋巴结情况不明或其他困难情况下,此二指标可辅助对预后的判断。 相似文献