排序方式: 共有2条查询结果,搜索用时 15 毫秒
1
1.
Han X 《Cellular and molecular life sciences : CMLS》2004,61(15):1896-1906
The critical roles of apolipoprotein E (apoE) in regulating plasma lipid and lipoprotein levels have been
extensively studied for over 2 decades. However, an understanding of the roles of apoE in the central nervous
system (CNS) is less certain. This review will summarize the available experimental results on the role of apoE
in CNS lipid homeostasis with respect to its modulation of sulfatide trafficking, alteration of CNS cholesterol
homeostasis and apoE-induced changes in phospholipid molecular species in specialized subcellular membrane
fractions. The results indicate that apoE mediates sulfatide trafficking and metabolism in the CNS. Moreover,
although apoE does not affect the cholesterol mass content or the phospholipid mass levels and composition in the
CNS as a whole, apoE modulates cholesterol and phospholipid homeostasis in selective subcellular membrane
compartments. Through elucidating the roles of apoE in CNS lipid metabolism, new insights into overall functions
of apoE in neurobiology can be accrued ultimately, leading to an increased understanding of CNS lipid metabolism
and the identification of novel therapeutic targets for CNS diseases.Received 9 January 2004; received after revision 28 February 2004; accepted 10 March 2004 相似文献
2.
Shao K Hou Q Go ML Duan W Cheung NS Feng SS Wong KP Yoram A Zhang W Huang Z Li QT 《Cellular and molecular life sciences : CMLS》2007,64(4):506-515
Tenascin-C is an extracellular matrix glycoprotein, whose expression is highly restricted in normal adult tissues, but markedly
up-regulated in a range of tumors, and therefore serves as a potential receptor for targeted anticancer drug or gene delivery.
We describe here a liposomal carrier system in which the targeting ligand is sulfatide. Experiments with tenascin-C-expressing
glioma cells demonstrated that binding of liposomes to the extracellular matrix relied essentially on the sulfatide-tenascin-C
interaction. Following binding to the extracellular matrix, the sulfatide-containing liposomes were internalized via both
caveolae/lipid raft- and clathrin-dependent pathways, which would ensure direct cytoplasmic release of the cargoes carried
in the liposomes. Such natural lipid-guided intracellular delivery targeting at the extracellular matrix glycoproteins of
tumor cells thus opens a new direction for development of more effective anticancer chemotherapeutics in future.
K. Shao & Q. Hou: These authors contributed equally to this work.
Received 22 September 2006; received after revision 5 December 2006; accepted 9 January 2007 相似文献
1