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Baud'huin M Lamoureux F Duplomb L Rédini F Heymann D 《Cellular and molecular life sciences : CMLS》2007,64(18):2334-2350
1997 saw the identification of a novel set of proteins within the tumor necrosis factor (TNF)/TNF receptor families that are
required for the control of bone remodeling. Therefore, these receptors, receptor activator of nuclear factor kappa B (RANK),
osteoprotegerin (OPG) and their ligand RANK ligand (RANKL) became the critical molecular triad controlling osteoclastogenesis
and pathophysiologic bone remodeling. However, the establishment of the corresponding knock-out and transgenic mice revealed
unexpected results, most particularly, the involvement of these factors in the vascular system and immunity. Thus, the OPG/RANK/RANKL
molecular triad appears to be associated with vascular calcifications and plays a pivotal function in the development of the
immune system through dendritic cells. OPG/RANK/RANKL thus constitute a molecular bridge spanning bone metabolism, vascular
biology and immunity. This review summarizes recent knowledge of OPG/RANK/RANKL interactions and activities as well as the
current evidence for their participation in osteoimmunology and vascular diseases. In fine, the targeting of the OPG/RANK/RANKL
axis as novel therapeutic approaches will be discussed.
Received 27 February 2007; accepted 4 April 2007 相似文献
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