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在高钾血症的研究中,制备一个稳定的动物模型是最基本和最重要的环节。文中通过3种方法制备高钾血症动物模型,(1)静脉滴注法;(2)静脉推注法;(3)腹腔给药法。通过3种不同的方法,都可以得到稳定的高钾血症动物模型。在具体的实验研究中,需根据实验目的和设计选择适当的模型的制作方法,以便取得最佳的实验结果。 相似文献
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R. Martinez B. Rietberg J. Skyler J. R. Oster G. O. Perez 《Cellular and molecular life sciences : CMLS》1991,47(3):270-272
Summary The effect of hyperkalemia on insulin secretion remains undefined. We evaluated portal and peripheral insulin levels in anesthetized dogs after infusions of KCl. The mean maximal increase in peripheral plasma potassium at infusion rates of 0.2 mEq/kg/h was 0.68±0.20 mEq/l. There were no significant increases in either portal or peripheral insulin levels. In contrast, in six dogs whose plasma potassium concentration increased in each case by more than 2.0 mEq/l (infusion rate of 0.5 mEq/kg/h), portal insulin levels increased fivefold (p<0.05). We conclude that only marked increases in plasma potassium concentration stimulate pancreatic insulin secretion. 相似文献
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