排序方式: 共有2条查询结果,搜索用时 15 毫秒
1
1.
短杆菌肽是一种被广泛研究的细胞膜中的多肽.其与磷脂之间的相互作用以及其在磷脂单层膜中的构象还不十分清楚.研究发现短杆菌肽D在卵磷脂单层膜中有自发形成聚集体的趋势,而且聚集体的形状依赖于短杆菌肽D在膜中的浓度.当浓度特别低时,聚集体很大;随着浓度的增加,聚集体逐渐变高但面积逐渐变小.特别是当短杆菌肽D的摩尔百分率达到10%时,聚集体几乎形成圆锥型 相似文献
2.
Transmembrane ion channels play a crucial role in the existence of all living organisms. They partition the exterior from
the interior of the cell, maintain the proper ionic gradient across the cell membrane and facilitate signaling between cells.
To perform these functions, ion channels must be highly selective, allowing some types of ions to pass while blocking the
passage of others. Here we review a number of studies that have helped to elucidate the mechanisms by which ion channels discriminate
between ions of differing charge, focusing on four channel families as examples: gramicidin, ClC chloride, voltage-gated calcium
and potassium channels. The recent availability of high-resolution structural data has meant that the specific inter-atomic
interactions responsible for valence selectivity can be pinpointed. Not surprisingly, electrostatic considerations have been
shown to play an important role in ion specificity, although many details of the origins of this discrimination remain to
be determined.
Received 4 September 2005; received after revision 17 October 2005; accepted 2 November 2005 相似文献
1