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通过对有机磷抑制人乙酰胆碱酯酶(AchE)和丁酰胆碱酯酶(BuchE)以及猪和牛丁酰胆碱酪酶活性的测定,发现人乙酰胆碱酯酶和丁酸胆碱酯酶对有机磷较为敏感,结果表明,该方法既灵敏又稳定. 相似文献
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Montenegro MF Ruiz-Espejo F Campoy FJ Muñoz-Delgado E de la Cadena MP Rodríguez-Berrocal FJ Vidal CJ 《Cellular and molecular life sciences : CMLS》2006,63(18):2175-2182
The aberrations of cholinesterase (ChE) genes and the variation of ChE activity in cancerous tissues prompted us to investigate
the expression of ChEs in colorectal carcinoma. The study of 55 paired specimens of healthy (HG) and cancerous gut (CG) showed
that acetylcholinesterase (AChE) activity fell by 32% and butyrylcholinesterase (BuChE) activity by 58% in CG. Abundant AChE-H,
fewer AChE-T, and even fewer AChE-R and BuChE mRNAs were observed in HG, and their content was greatly diminished in CG. The
high level of the AChE-H mRNA explains the abundance of AChE-H subunits in HG, which as glycosylphosphatidylinositol (GPI)-anchored
amphiphilic AChE dimers (G2A) and monomers (G1A) account for 69% of AChE activity. The identification of AChE-T and BuChE mRNAs justifies the occurrence in gut of A12, G4H and PRiMA-containing G4A AChE forms, besides G4H, G4A and G1H BuChE. The down-regulation of ChEs might contribute to gut carcinogenesis by increasing acetylcholine availability and overstimulating
muscarinic receptors.
Received 19 May 2006; received after revision 5 June 2006; accepted 5 July 2006 相似文献
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