Internalization of triiodothyronine-bovine serum albumin-colloidal gold complexes in human peripheral leukocytes

Summary Complexes of triiodothyronine-bovine serum albumin-colloidal gold were specifically internalized in human peripheral leukocytes after 5 min of incubation. The specifity was partially lost after a longer incubation.     

Binding of (125I) triiodothyronine to human peripheral leukocytes and its internalization

Summary Ultrastructural autoradiography showed high specific binding of (¹²⁵I) triiodothyronine, as confirmed by a competition test, to plasma membranes, nuclei and mitochondria of human peripheral leukocytes. A high level of binding was also noted on the granulocytes' granules, especially in eosinophils.     

Evidence of a direct action of triiodothyronine (T3) on the cell membrane of GH3 cells: an electrophysiological approach

Summary Electrophysiological experiments demonstrate that triiodothyronine (T₃) exerts a direct effect on the membrane of a strain of cultured rat pituitary tumor cells, GH₃/B₆. These cells respond to pressure application of T₃ (2–5 nl, concentration 1·10^–10 M) with an increase in the membrane resistance (R_m) and a hyperpolarization. Spontaneously firing cells become silent.