“百病生于气”疾病观的针灸临床应用

 “百病生于气”见于《素问·举痛论》，几千年来始终是中医临床认识疾病、防治疾病的重要理论依据之一。对气的含义及气机失调致病的机制进行了梳理，得出了“百病生于气”的基本含义可以概括为气机失调是疾病发生的基本病机的结论，情志因素、精神心理是导致疾病发生的重要内因。分析认为“百病生于气”的理论对于针灸临床有重要指导意义，针灸诊疗过程中应注重“调气”“调神”，这是针灸取得佳效的根本保障。     

乌鸡白凤口服液扶正固本作用的动物实验观察

目的 :观察乌鸡白凤口服液的益气养血功能 ,比较乌鸡白凤口服液与乌鸡白凤丸二种剂型的作用差异。方法 :观察药物对急性小白鼠血虚模型的影响及对小白鼠急性应激反应的影响。结果 :乌鸡白凤口服液能显著促进失血小鼠 RBC,Hb值的恢复 ,能显著提高小鼠的抗应激能力 ,延长小白鼠常压缺氧死亡时间及延长小白鼠游泳时间。乌鸡白凤丸也是具有相似的作用。结论 :乌鸡白凤口服液具有补气养血 ,升高血红蛋白 ,提高红细胞值的作用     

欹器与半坡尖底陶罐

本文从词意和力学角度对欹器和半坡尖底陶罐进行研究,认为半坡尖底陶罐是欹器的可能性很小;另外对欹器的构造进行了设想。     

论黄宗羲思想的民主内涵及其历史地位

黄宗羲在《明夷待访录》中提出了一个系统批判君主专制制度、主张实行社会改革的具有民主启蒙性质的政治思想纲领,从而奠定了他作为中国17世纪最伟大的民主启蒙思想家的历史地位。他的“君为民害”论和“民主君客”论,批判了君主专制,伸张的是主权在民、君须为民服务的思想;他提出“藏天下于天下”“贵不在朝廷,贱不在草莽”之说,具有民治、民享、人权平等的思想倾向;“公其非是于学校”的主张,则是对人民议政权和监督权的肯定。     

平补脾肾法治疗肾脾气（阳）虚型慢性肾衰的临床观察

观察中医药平补脾。肾法治疗肾脾气（阳）虚型慢性肾衰临床疗效。方法：随机采用观察组164例与对照组167例,在常规治疗的基础上,观察组采用中药汤及灌肠两种方法;对照组采用包醛氧淀粉、大黄胶囊及药用炭口服。结果：治疗组不仅可改善慢性肾功不全失代偿期患者的肾功能和临床症状、体征,而且可以使患者的体质、体力得以恢复,生存质量明显提高,且各方面的指标均显著优于对照组,在2年期疗效观察中,治疗组的病情稳定的人数明显的多于对照组。结论：平补脾肾法治疗慢性肾功能衰竭临床疗效显著。     

马浮经学的本体诠释学

马浮的学术特色在其经学的本体诠释学,他将六艺统归于一心,而此心又上遂于道.然而.值得注意的是,他又不赞成直说"心即理",而强调"理气""性情"两端而一致的辩证圆融.他的六艺之教所涵的"相涵互摄""体用一如"的思想,隐含着一套完整的本体诠释学的思维.马浮以"六艺统摄诸子",进而以六艺统摄四部,进而以六艺统摄西来学术,终究言之,它要以六艺统摄天下之道.若据学问之实而言之,马浮之论不免稍过,但若能人乎其中,将可以发现马浮之学所涵之本体诠释学可以经一"因而通之""调适而上遂于道"的方法,而有一崭新发展之可能.再者,我们将集中"道""经典""人"这三端的互动循环,对比讨论经学本体诠释学的诸多相关问题.     

脾气虚证动物模型规范化的初步研究——部分免疫功能方面

目的　在脾气虚证动物模型规范化的初步研究中 ,探讨其部分免疫功能改变。方法　首先改进、完善脾气虚证模型的诊断标准和造模方法 ,然后观察其部分细胞免疫、非特异性免疫、红细胞免疫功能改变 ;同时与 5种目前有代表性的脾气 (阳 )虚证模型进行比较。动物采用WistarⅡ级大鼠 ,雄性 ,分为对照组、初步规范组、大黄组、耗气破气组、限量营养组、劳倦过度组和利血平组。初步规范组采用体质、苦寒泻下加耗气破气降气法造模 ,其他模型组采用相应常规方法造模。取样检测指标前进行游泳或寒冷负荷。结果　从胸腺湿重和指数 ,胸腺皮质厚度 ,脾脏中央动脉周围淋巴鞘直径 ,脾脏T淋巴细胞增殖功能 ,脾脏NK细胞对YAC 1肿瘤细胞杀伤率 ,脾脏巨噬细胞中性红吞噬活性等指标的改变看 ,初步规范组的造模结果与脾气虚证模型诊断标准有较高的符合率 ,包括自然恢复较慢 ,且与诊断标准的符合率明显优于目前 5种有代表性的脾气 (阳 )虚证模型。结论　本实验达到了初步优化、规范脾气虚证模型的目的。     

词义札记二则

前贤对古文的注释多有商榷之处。本文围绕古文“更取器用”之“更”和“众不见信”之“众”、“见”的训释进行讨论和辨析,提出释“更”为“取”,“众”不作“终”训,“见”当属指代用法．     

现代语言的模仿与表现

从史论结合的角度探讨模仿语言与表现语言的特征、功能及其语体建构,深度触及了模仿语言和表现语言的内在结构,解决了形式主义语言学中的两个大问题。     

Effects of Chinese herbs capable of replenishing qi, nourishing yin and activating blood circulation and their compatibility on differentially expressed genes of ischemic myocardium

This study was conducted to investigate the effects of Chinese herbs capable of replenishing qi, nourishing yin and activating blood circulation and their compatibility on differentially expressed genes of ischemic myocardium which were selected from differential expression profile we had established before, and to explore the underlying mechanism. The acute myocardial infarction （AMi） model was established by ligating the left anterior descending （LAD） coronary artery, then the model rats were randomly divided into the model group, the Metoprolol group, the replenishing qi nourishing yin （RN） group, the activating blood circulation （AB） group, and the replenishing qi, nourishing yin and activating blood circulation （RA） group. In addition, the normal group and the sham group were set up. The rats of medication groups were administered by intragastric gavage with corresponding drugs on the second day after operations, and the rats of the normal group and the sham group were given normal saline as the same time.Then the ischemic hearts were harvested on the 8th day after operation. The myocardial pathomorphological changes were observed under a light microscope. The mRNA changes of target genes such as COX5a and ATP5e were detected using Real-time fluorescence quantitative PCR （Q-PCR）, and the activities of related enzymes were detected by colorimetric assay. The main resuits were as follows： the histological changes were observed by HE staining, and cardiocyte swelling, inflammatory cell infiltration and cytolysis were showed in regional ischemic myocardium of the model group, while the pathomorphological changes in all medication groups did not show obvious changes. Two genes related to energy metabolism, COX5a and ATP5e, were selected as the target genes which were down-regulated at the mRNA level in the medication groups. The activities of correlative functional enzymes also decreased in the RA group compared to that in the model group accordingly （P〈0.05）. The results indicated that the abnormal expression of genes involved in energy metabolism pathways could be one of the molecular mechanisms of AMI. The compatibility of Chinese herbs capable of replenishing qi, nourishing yin and activating blood circulation affects the expression of energy-relative gene COX5a, ATP5e, which is probably the mechanism of myocardial preservation, and is more effective than single herb of replenishing qi and nourishing yin or activating blood circulation.