The effect of moderate hemodilution with Fluosol-DA or normal saline on acetaminophen disposition in the rat

Summary Hemodilution with 40 ml/kg of Fluosol or saline reduced the acetaminophen V_d and the acetaminophen sulfate Cl_M at 48 or 72 h, respectively. Fluosol hemodilution increased the acetaminophen renal excretion at 24 and 72 h. But at 48 h, Fluosol hemodilution either inhibited the renal secretion of acetaminophen or enhanced its reabsorption.