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排序方式: 共有117条查询结果,搜索用时 15 毫秒
1.
D. Migliore-Samour M. Delaforge M. Jaouen D. Mansuy P. Jollès 《Cellular and molecular life sciences : CMLS》1989,45(9):882-886
Summary Immunomodulating lipopeptides lauroyl-L-Ala--D-Glu-LL-A2pmNH2-Gly (RP 44.102) and lauroyl-L-Ala--D-Glu-LL-A2pmNH2 (RP 56.142) were found to protect mice against the hepatotoxicity of paracetamol, which is due to cytochrome P-450 dependent formation of toxic metabolites and radicals. In fact they decreased the amount of hepatic microsomal cytochrome P-450, and the level of CCl4-induced lipid peroxidation. In contrast lauroyl-L-Ala--D-Glu-DD-A2pmNH2 (RP 53.204), which only differs by the configuration of the two chiral carbons of A2pm (diaminopimelic acid) and is not an immunomodulating agent, failed to protect against poisoning by paracetamol and had no effect on the level of hepatic cytochrome P-450 or the microsomal CCl4-induced lipid peroxidation. This provides a clear connection between the immunostimulating properties of a compound and its effects on xenobiotic biotransformations. 相似文献
2.
Lu Wei-bing Wang Cun-xin Deng Li-zhi Zhou Xiao-hai Ren Jian-guoCollege of Chemistry Molecular Sciences Wuhan University Wuhan Hubei China 《武汉大学学报:自然科学英文版》2003,8(2):428-432
A new dinucleating ligand having two metal-binding sites has been designed and synthesized as model ligand for Cytochrome c Oxidase. The corresponding heterodi-nuclear complex, as an active site model of Cytochrome c Oxidase, consisting of a porphyrinatocobalt compound covalently linked with a copper derivative of tris(2-benzimidazylmethyl) amine bearing three benzimidazole ligands for copper was synthesized and spectroscopically characterized. The spectra data suggest that there are interactions between the cobalt and copper coordination units. The cobalt is coordinated to four central nitrogens of the porphyrin and the copper has pentaco-ordinate geometry with the four tertiary amine nitrogens and a chloride. 相似文献
3.
应用循环伏安法研究了细胞色素c在2-氨基乙硫醇自组装膜修饰金电极上的电化学行为。结果表明,细胞色素c在2-氨基乙硫醇修饰的金电极上的电子传递过程为—扩散控制的可逆反应,2-氨基乙硫醇自组装膜可用作细胞色素c电子传递的有效促进剂。依据电化学石英晶体微天平和电化学交流阻抗谱的测量结果,讨论了单分子膜的组装过程及其对促进细胞色素c电子传递的作用机制。 相似文献
4.
5.
Thanade Nonsrirach 《Journal of Natural History》2019,53(13-14):849-861
Glyphoglossus molossus, is one of the most economically important amphibians in the Khorat Plateau, north-eastern Thailand. It is categorised as a near-threatened species by IUCN due to over-exploitation. Here, we examined the genetic structure of G. molossus using partial mitochondrial cytochrome-b gene sequences from specimens collected at 11 localities. The sequence analysis revealed the presence of 15 haplotypes, 5 of which are shared by 2 or more populations, and 10 haplotypes that are confined to a single population. The relatively low haplotype (h) and nucleotide (π) diversities suggest that the Phu Phan Mountain Range is not high enough to act as an effective dispersal barrier between the Sakon Nakhon and Khorat Basins. However, AMOVA and phylogenetic analyses based on Maximum likelihood (ML) and Bayesian inference (BI) strongly supported the presence of two genetically divergent clades, Sakon Nakhon Basin and the northern part of the Khorat Basin (clade A) and the southern part of the Khorat Basin (clade B). These two lineages are separated by substantial geographical distance, which has putatively resulted in a reduction of gene flow. Further studies, with more extensive genetic sampling, especially from throughout the species range will aid in better interpreting our results. 相似文献
6.
IntroductionLong chainα,ω- dicarboxylic acids (DCA ) areversatile chemical intermediates used as rawmaterials for the preparation of perfumes,polymers,and adhesives[1] .Various strains of C.tropicalis are known to produce DCA whencultured with alkanes or fatty acids as the carbonsource[2 ,3] . During aerobic and viscous fermentation,theoxygen supply is of crucial importance becauseinsufficient oxygen can lead to suboptimalproductivities[4 ] as well as products of low quality.Several meth… 相似文献
7.
D. P. Keogh M. J. Mitchell J. R. Crooks S. L. Smith 《Cellular and molecular life sciences : CMLS》1992,48(1):39-41
The adenylate cyclase activator forskolin and its pharmacologically inactive derivative 1,9-dideoxyforskolin were found to inhibit in a dose-dependent fashion the ecdysone 20-monooxygenase activity associated with wandering stage larvae ofDrosophila melanogaster and fat body and midgut from last instar larvae of the tobacco hornworm,Manduca sexta. The concentrations of these labdane diterpenes required to elicit a 50% inhibition of the cytochrome P-450 dependent steroid hydroxylase activity in the insect tissues ranged from approximately 5×10–6 to 5×10–4 M. 相似文献
8.
用P538分离富集微量钪 总被引:2,自引:0,他引:2
探讨了P-538萃取钪的条件。和Th~(4 ),Ce~(4 )相似,P-538对钪有极好的萃取能力,即使在高酸下也近于完全萃取,因而可用于钪与其它元素(除Th~(4 )与Ce~(4 )外)的分离,萃合物的组成经测定为Sc(HA)_3。 相似文献
9.
为了满足我国西南偏远农村对通信的需求以及运营商的投入成本高的问题,村通工程CDMA450广泛应用与西南农村地区.对于一个以广覆盖为目标,采用450 MHz频段的CDMA-1X网络,前期网络规划在很大程度上决定了网络的结构,对网络投资以及质量起着决定性作用,是将来网络发展的基础,而给出了CDMA450网络的详细规划流程,以及后期扩容的有效方案,旨在为运营商建网提供决策参考. 相似文献
10.
为了满足我国西南偏远农村对通信的需求以及运营商的投入成本高的问题,村通工程CDMA450广泛应用与西南农村地区。对于一个以广覆盖为目标,采用450 MHz频段的CDMA-1X网络,前期网络规划在很大程度上决定了网络的结构,对网络投资以及质量起着决定性作用,是将来网络发展的基础,而给出了CDMA450网络的详细规划流程,以及后期扩容的有效方案,旨在为运营商建网提供决策参考。 相似文献