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Introduction Transmitter secretion requires specialized secretory or- ganelles, the synaptic vesicles, for the packaging, stor- age, and exocytotic release of the transmitters[1,2]. The neurotransmitter acetylcholine (ACh) is released at the neuromuscular… 相似文献
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TANWenchang LIUShiqiang GUOJingjing WANGShiqiang CHENGHeping T.Masuok 《科学通报(英文版)》2003,48(23):2564-2567
A new dynamic model for non-Fickian diffusion of calcium spark in cardiac myocytes was developed by introducing time lags on the basis of the microscale mass transport theory. Numerical simulation showed that the size of the calcium spark produced by the new dynamic model was larger than that of Fick diffusion and was in more agreement with experimental results. In addition, the time lags of the calcium spark in cardiac myocytes were about 0.1--0.8 ms. These results can be used to understand the mechanism of calcium spark diffusion in cardiac myocytes. 相似文献
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Insulin improves cardiac myocytes contractile function recovery in simulated ischemia-reperfusion: Key role of Akt 总被引:6,自引:0,他引:6
ZHANG Bo ZHANG Haifeng FAN Qian MA Xinliang & GAO Feng Department of Physiology The Fourth Military Medical University Xi抋n China Correspondence should be addressed to Gao Feng 《科学通报(英文版)》2003,48(13):1364-1369
There are abundant insulin receptors on the membrane of myocytes, which renders cardiomyocytes typical target cells of insulin. Accumulating evidence has indicated that abnormal insulin level is an important predisposing factor in diabetes-related cardiovascular disorders and may contribute to the development of cardiovascular diseases, such as coronary heart diseaseand heart failure. It has been shown that insulin couldreduce infarct size in experimental animals subjected to myocardial ischem… 相似文献
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紫彩血蛤肾脏和围心腔腺的超微结构 总被引:1,自引:0,他引:1
用透射电镜观察了紫彩血蛤(Nuttallia olivacea)的肾脏和围心腔腺的超微结构。在肾脏中观察到4种细胞:具液泡的立方形细胞、具液泡的长柱形细胞、吞噬细胞和肌细胞。在围心腔腺中观察到3种细胞:柱状上皮细胞、实质细胞和吞噬细胞。肾脏中除了肌细胞外的3种细胞及围心腔腺中除了柱状上皮外的2种细胞内均有色素颗粒,它们能将色素颗粒转化降解。 相似文献
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心室肌细胞存在持续性钠电流的特征与心脏其他类型的钠通道电流不同。某些药物,如利多卡因、奎尼丁、藜芦宁、R56865,Anthopleurin,TTX等)及病理、生理状态可影响此电流。此外,该电流可影响动作电位形态,加强心室肌细胞的去极化,并与早期后除极相关,参与心律失常的形成。对INa.p所引起的不同反应及其发生机制的研究,有助于了解机体内外环境紊乱时心律失常的发生机制。 相似文献
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本研究在体外建立心肌细胞缺血再灌注模型.利用透射电镜、MTT,流式细胞技术,及乳酸脱氢酶活性检测细胞活性和Western Blot分析等方法探讨异鼠李素对心室肌细胞缺血再灌注损伤的作用.发现缺血再灌注心室肌细胞出现明显的细胞凋亡现象,电镜观察细胞超微结构发生明显改变,MTT,流式细胞技术,及乳酸脱氢酶活性结果显示I/R+/isor+组心肌细胞活性与I/R+/isor相比明显增强,细胞凋亡程度减弱;Western Blot也表明与I/R+/isor组相比,I/R+/isor+组心室肌细胞中Bcl-2蛋白表达明显上调,Bax及p53蛋白表达明显下降, Bcl-2/Bax比率显著减小.从实验结果显示异鼠李素对心肌缺血再灌注损伤具有一定的保护作用,其作用与药物浓度有关,低浓度的异鼠李素对心肌具有保护作用,且药物浓度越大,保护作用越强;而高浓度的异鼠李素则随药物浓度的增加对心肌的保护作用逐渐减弱,甚至出现一定的细胞毒性. 相似文献
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采用透射电子显微镜技术,研究了新型吡唑酰胺类衍生物WJ-H7对小菜蛾(Plutella xylostella)体壁肌细胞超微结构的影响。电镜观察发现,化合物WJ-H7对小菜蛾幼虫体壁肌细胞具有明显毒性;中毒幼虫肌细胞,特别是质膜和内膜系统以及肌原纤维发生明显病变,表现为核膜部分消解,细胞核固缩或核质溶出,核与肌原纤维的间距增大,肌原纤维间间距增大,肌丝部分消失,线粒体消失;结果表明,肌细胞可能是化合物WJ-H7的一个作用部位。 相似文献
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