Therapeutic applications of bone marrow-derived stem cells in liver transplantation for end-stage liver diseases

Today, liver transplantation (LT) is the only established treatment for end-stage liver diseases. The de- velopment of LT, including OLT, cadaveric LT, split LT, living donor LT (LDLT), brings hopes to patients with these diseases. However, increasing donor shortage, rejection and life-long immunosuppression with its side effects are the major limitations of this therapy strategy. Bone marrow-derived stem cells (BMDSCs) are capable of differentiating into hepatocyte-like cells and contribute to liver injury repair. The microenvironment of liver injury caused by rejection, ischemia/reperfusion, loss of liver mass, recurrence of HCV and "small-for-size syndrome" after LT can attract a variety of bone marrow-derived stem cell population to the peripheral circulation and then migration to the injury liver to promote the hepatic function restoration. Additionally, BMDSCs can also take part in the functional regeneration of living donor liver after LDLT. This participation in liver regeneration may be associated to the interac- tion between SDF-1and its receptor CXCR4, involving HGF, IL-8, MMP9, and VEGF/VEGFR-2. BMDSC with its bio-characteristics could maintain the allograft tolerance from different angles and in different ways. In conclusion, BMDSCs transplantation, as a new assistant therapeutic method for LT, will ex- pand the space of LT, and provide more survival opportunities for the patients suffering liver diseases in the future.     

晚期帝国叙述的话语分析

库切在《等待野蛮人》中通过对晚期帝国叙述的话语分析,告诉人们:帝国的叙述是帝国别有用心地站在单向的透视视角上运用多种技术、策略建构权威的过程,语言、书写符号、法律等都参与其中。这样获得的权威并不稳固,当帝国权威赖以获得的野蛮人消失时,帝国便会无所适从,而陷入崩溃。     

根癌农杆菌介导AtNHX1基因转化小麦

利用根癌农杆菌对 3种基因型小麦进行了转化研究 .发现基因型对转化有明显影响 .将小麦品种烟优 36 1、烟 10 3、核生 3号的胚性愈伤组织用含报告基因NPTⅡ和抗盐基因Na H 反向转运AtNHX1的农杆菌菌株pROK2AT GV310 1感染和共培养后 ,用巴龙霉素 5 0 - 15 0mg L筛选抗性愈伤组织及转化植株 .对抗性植株的总DNA用AtNHX1基因的特异引物进行PCR检测 ,目的基因的PCR阳性频率为 1.3(烟 10 3)和 2 .9% (核生 3号 ) .Southern杂交证实外源基因已经整合到小麦的基因组中     

华北克拉通恒山地区晚太古代变质火山岩的地球化学特征及构造意义

对恒山地区出露的变质火山岩开展岩相学、地球化学、锆石U-Pb年代学和Hf同位素研究,旨在确定其形成时代,探讨岩石成因及地球动力学意义。锆石U-Pb定年结果表明,这些变质火山岩喷发于新太古代晚期(2508±20Ma)。地球化学分析结果显示,恒山变质火山岩由变质玄武岩和变质玄武安山岩组成,SiO₂(45.51%～62.67%)、FeO_T (4.43%～15.72%)和MgO (3.75%～8.14%)含量变化幅度大,是幔源岩浆经单斜辉石、角闪石和磁铁矿分离结晶的产物。这些变质火山岩富集轻稀土(LREE)和大离子亲石元素(LILE),亏损重稀土(HREE)和高场强元素(HFSE),具有相对高的Th含量和Th/Yb比值,呈现钙碱性岛弧火山岩的特征。结合不相容元素比值Nb/Yb,Zr/Yb和(Nb/La)_N的特点,推测其来源于俯冲带具流体交代特征的富集地幔源区。结合区域构造背景,推断恒山变质火山岩形成于新太古晚期大陆弧环境。     

运动与防癌

在癌发生的诱发阶段和促进阶段均有自由基参与,多数诱癌因素和促癌因素可通过自由基介导癌变过程．适量的运动可以降低自由基水平,坚持运动有助于防癌．     

美施康定对癌症疼痛的镇痛效果

本组５４例重度癌痛晚期病人,给予口服美施康定３０～９０ｍｇ每１２ｈ一次治疗,有效率达９６３％（５２／５４）,完全缓解率达８７％（４７／５４）,主要副作用为便秘、恶心、呕吐、嗜睡等