Using of the surface plasmon resonance cytosensor for real-time and non-invasive monitoring of cellular effects in living C6 cells induced by PMA

By cell and molecular biology, the traditional life science research has been improved into modern ex-perimental science. Because cell is the basic structural and functional unit of the mysterious life, the study of life phenomena will be ultimately embodied into the study of cell biology. How to acquire a dynamic knowledge of the intricate biomolecular reactivity and process in living cells has become one of the hotspots in recent biological researches. For the complexity of cellular effects,…     

探地雷达应用于植物粗根探测的研究进展

应用探地雷达开展植物粗根探测始于1999年,经过15年的验证与发展,其粗根探测的有效性和精度已在不同探测物种和不同实验条件下得以证实。作为一种非侵入性的地球物理探测手段,探地雷达探测粗根的方法不但克服了传统根系调查耗时费力且破坏性较大的限制,并使得野外大面积重复性粗根观测成为可能。近几年,探地雷达粗根探测在粗根雷达信号正演模拟方法的建立,影响粗根探测精度的敏感因素分析,粗根生物量反演方法的改进和根系三维结构的重建等方面取得了进展,完善了探地雷达探测粗根的方法和流程,拓展了非侵入性根系探测的研究范围。随着探地雷达系统、数据处理软件和雷达数据采集方式的进一步改进,探地雷达在根系探测领域必将展示出更大的潜力。     

美军用电击术造不眠战士

据说，五角大楼感觉咖啡和功能性饮料不足以阻止士兵的思想开小差，为此，美军开始试验用低水平电击法让士兵在战斗中保持警觉。初始试验对数十名志愿者使用“非侵入性”大脑电击术，结果这些人似乎表现得更出色。据《波上顿环球报》报道，其中一位研究人员林赛·麦克英塔尔表示，这比咖啡因的反应更好，而且没有神经过敏或者心悸等副作用。     

非侵入性机械通气治疗急性呼吸衰竭

以往对于急性呼吸衰竭的病人,常规治疗失败,需要进行机械通气,但侵入性机械通气可引起许多并发症,所以人们转向非侵入性机械通气的应用研究,企图避免侵入性机械通气的并发症,并能达到相似的治疗效果.本文分析和总结了非侵入性机械通气的作用机制、适应症、禁忌症及呼吸模式的合理选用.     

非侵入性机械通气治疗急性呼吸衰竭

以往对于急性呼吸衰竭的病，常规治疗失败，需要进行机械通气，但侵入性机械通气可引起许多并发症，所以人们转向非侵入性机械通气的应用研究，企图避免侵入性机械通气的并发症，并能达相似的治疗效果，本文分析和总结了非侵入性机械通气的作用机制，适应症，禁忌症及呼吸模式的合理选用。     

利用大脑活动图谱寻找神经元代码开启之锁

科学家们虽经几十年的研究,但迄今仍未搞清楚神经元放电是如何解码人类思想和行为的。为了解开此过程之谜,一组科学家提出了一项雄心勃勃的大脑活动图谱(BAM)项目计划,旨在将大脑中每一根神经元活动绘成图谱,     

用电流增强记忆

美国西北大学医学院的一项新研究报告说,通过用磁脉冲交付非侵入性电流来刺激大脑的特定区域,被称为＂经颅磁刺激＂（以下简称TMS）,可以提高记忆力。这一发现开辟了一个新的领域,可能用于治疗如中风、早期老年痴呆症、创伤性脑损伤和心脏骤停情况引起的记忆缺陷以及在老龄化过程中发生的记忆问题。     

An on-line multi-parameter analyzing optical biosensor for real-time and non-invasive monitoring of plant stress responses in vivo

Photosynthetic dysfunction and reactive oxygen species （ROS） production are the common features of plant stress responses. Based on quantitative measurement of ROS production and delayed fluorescence （DF） emission, which is an excellent marker for evaluating photosynthesis, an on-line multiparameter analyzing optical biosensor for detecting plant stress responses was developed. Performances of the proposed biosensor were tested in the wild type （WT） Arabidopsis and heat shock protein （Hsp） 101 T-DNA knockout mutant （hsp101） plants with different thermotolerance. Results demonstrated that DF intensity correlates with net photosynthesis rate （Pn） in response to elevated temperature in both the WT Arabidopsis and hsp101 mutant plants. The light response characteristics and the recovery dynamics of the DF intensity were also in line with those of Pn in both the WT Arabidopsis and hsp101 mutant plants after heat stress （HS, 40℃ for 30 min）, respectively. In all experiments discussed above, the hsp101 plant showed the worse photosynthetic performance than the WT plant. Moreover, after HS, more ROS production in the hsp101 mutant than in WT Arabidopsis, which was found to be mainly localized at chloroplasts, could be directly detected by using the proposed biosensor. In addition, the hsp101 mutant showed severer chloroplasts alterations than the WT plant within the first 1 h of recovery following HS. Nevertheless, pre-infiltration with catalase （CAT） reduced ROS production and prevented the declines of the DF intensity. Therefore, HS-caused declines of photosynthetic performance might be due to oxidative damage to photosynthetic organelle. To sum up, we conclude that Hsp101 plays an important role in preventing oxidative stress, and the proposed optical biosensor might be a powerful tool to determine plant stress responses and identify plant resistant difference.     

乳腺癌预后有了新生物标记

正预后良好的患者可幸免进行带有严重副作用的侵入性治疗,但不对侵入性肿瘤进行侵入治疗或可导致死亡。癌症之所以致命,在很大程度上是由于其发生了转移,从一个器官或组织转移到另一个器官或组织。癌症致死绝大多数与转移有关。对于乳腺癌来说,被称为"上皮间质转化"的过程助推了这种转移。上皮细胞系附着在与环境接触的皮肤和胃肠道中。间质细胞是胚胎组织和结缔组织中的一种细胞类型,其在那里形成非常松散的联系。肿瘤细     

秘踪病毒的发现者埃丝特·莱德伯格逝世

鉴别出侵入性细菌并藏匿细菌DNA中伺机破坏的秘踪病毒的微生物学家埃丝特·莱德伯格（Esther Lederberg）,2006年11月11日因充血性心力衰竭和肺炎引起的并发症在美国加利福尼亚的斯坦福逝世,享年83岁。