IGF-PI3K-Akt信号通路在生理性心肌肥大中的作用研究进展

心肌肥大是心肌细胞对多种刺激因素的复杂反应。心肌肥大可以分为三种:心肌的正常生长、运动诱导生理性心肌肥大和病理性心肌肥大。近年来,研究表明心肌的正常生长以及运动诱导的心肌生理性肥大,主要是通过IGF-PI3K-Akt信号通路进行信号转导。本文就IGF-PI3K-Akt信号转导通路的结构特点、调节过程作一综述。     

SARS研究进展

本文对SARS病原学、流行病学、预防和治疗的研究进展进行了综述。     

断裂带作为油气散失通道的输导能力

通过断裂散失的油气量主要与断裂带的输导能力、实际进入断裂带的油气量、断裂通道的长度、散失时间和储层分流系数等参数有关。断裂带输导能力的主要因素是断裂带的宽度和储层渗透率。利用断裂散失模型计算了不同规模的断裂带作为油气散失通道的输导能力。计算结果表明 ,大型断裂带输导油气的能力远大于储层输导油气的能力。断裂活动期进入“通天”大断裂带的油气主要趋于散失 ;小断裂由于储层的分流作用 ,即使在活动期 ,它作为油气散失通道的作用也是有限的 ,其油气的散失量可以忽略不计。     

Indoxyl derivatives of drug metabolites

Summary Indoxyl derivatives were detected as minor products among the urinary metabolites of two trial drugs, a benzodiazepine (GP 55 129) and a benzophenone (CGP 11 952). Their structures were elucidated by NMR and mass spectroscopy. Presumably, metabolites containing potential aldehyde functions react spontaneously with endogenous indoxyl. Such derivatives have not hitherto been encountered in drug metabolism.     

排球运动中的供能特点与营养补充

物质和能量代谢是人体各组织器官机能活动的基础，应用运动时物质和能量代谢规律指导训练期间的营养安排是非常有益的．通过对排球运动的特点进行分析，结合各供能系统的特点以及各种能量物质分解的先后关系，简要陈述排球比赛中的物质和能量代谢，分析了排球运动中疲劳产生的可能原因，有针对性地提出训练中的营养安排以及应当注意补充的几种营养物质。     

对逐级递增负荷力竭性运动前后自由基代谢的灰色关联分析

采用灰色关联分析方法研究了逐级递增负荷力竭性运动前后自由基代谢指标的变化，结果显示，自由基代谢系统不同成分之间的相互影响是非常复杂的；尿液T—SOD的变化可能主要受到肾脏本身自由基代谢状态的影响；机体各组织细胞中生成的MDA对尿液MDA含量的变化有重要影响．     

蒙药治疗呼吸系统疾病研究进展

回顾了古代“丝绸之路”推动蒙医药的发展历程,分析了现代“一带一路”倡议发展思想下,蒙医药的发展机遇。介绍了蒙医药理论体系中经典的三要素理论,列举了蒙医治疗不同呼吸疾病（慢性阻塞性肺疾病、支气管哮喘、肺癌、肺部感染性疾病、新冠肺炎、肺纤维化等）的主要药物与疗法。从临床应用、有效成分挖掘与作用机制研究等方面,综述了近年来蒙医药在呼吸疾病领域中的应用情况和研究进展。     

The phytotoxins ofMycosphaerella fijiensis,the causative agent of Black Sigatoka disease of bananas and plantains

Black Sigatoka is the most costly to control disease of bananas and plantains in the world. Currently, a worldwide search is underway either to find or to produce cultivars that are disease-resistant or-tolerant. Phytotoxins isolated from the pathogen might facilitate the discovery of such cultivars. Several aromatic compounds from liquid cultures ofMycosphaerella fijiensis, the causal agent of Black Sigatoka disease of bananas and plantains, have been isolated. The most abundant and phytotoxic of these compounds is 2,4,8-trihydroxytetralone, which induces necrotic lesions at 5 g/5 l in less than 12 h on sensitive cultivars of bananas. This compound exhibits host-selectivity that mimics that of the pathogen. Other phytotoxins isolated from this fungus, in lesser amounts, were juglone, the novel compound 2-carboxy-3-hydroxycinnamic acid, isoochracinic acid and 4-hydroxyscytalone. Some of the phytotoxins isolated are melanin shunt pathway metabolites, which makes this fungus unique among plant pathogens.     

Metabolism of 3β-hydroxycholest-5-en-26-oic acid in hamsters

Summary Metabolism of 26-hydroxycholesterol to 3-hydroxychol-5-en-24-oic acid and other C24-bile acids has been expected to occur by way of 3-hydroxycholest-5-en-26-oic acid in studies in vitro. 3-Hydroxycholest-5-en-26-oic acid was infused intravenously into bile fistula hamsters and the following C24-bile acids were identified: 3-hydroxychol-5-en-24-oic acid, lithocholic acid, chenodeoxycholic acid, and a small amount of cholic acid.     

Milestone of the meridian science──970th anniversary of the Chinese Bronze Statue of Meridian

For more than a thousand years, Chinese people were aware of the transmitted sensations by the application of needles on the body surface. This practice is called acupuncture. Acupuncture had been recorded and transcribed in writings and in drawings, until finally the acupoints were inscribed onto a bronze statue. The bronze statue was called the Meridian Figure. Deeply embodied in the bronze statue is a tripartite confrontation-prism representation of the humans body. This concept was a great scientific achievement in ancient China. The author traces the history of Meridian science described in traditional Chinese medical terms. Then he explores a clear analogy of the meridian pathway (MP) phenomenon. In a model system, by using a simple segmental in vertebrate, certain parallels can be demonstrated with the meridian concept. For example, the author demonstrated a clear correlation rule among the central mechano-sensory channels, and characteristics of positional discrimination in individual nerve cells from different receptive field inputs. The evidence suggests that the MP phenomenon is an objective neurobiological response. To clarify the research objective in this paper, the author suggests that the MP is a bi-directional pathway along which a positional message signal is transmitted. This phenomenon is evoked by physical stimulation, transmitted linearly across the human body segments, and is perceived by the brain. The MP consists of low resistance paths, is connected by the liquid media contained in the apposite membranous structure. At the cellular level, the regulation functions of MP must pass through along this low resistance path. Two aspects of the modern Meridian research are the functional regulation and the mechanism of intercellular liquid modulation at the nanometer level.