电泳沉积羟基磷灰石生物陶瓷涂层的研究

用异丙醇作为分散介质，对电泳沉积羟基磷灰石生物陶瓷涂层进行了系统研究，经过制备稳定的悬浮液、电泳沉积，高温烧结等过程，在Ti6A14V合金上得到表面均匀的羟基磷灰石生物陶瓷涂层，用X射线衍射（XRD）和扫描电镜（SEM）等技术对羟基磷灰石颗粒的物相和沉积层的表面进行了表征，研究了电泳时间与电泳沉积量和电流密度，电泳沉积量和电泳电压之间的相互关系，并讨论了这些实验参数对电泳沉积过程的影响。     

多孔β—磷酸三钙骨修复材料的制备

提出制备β－磷酸三钙陶瓷粉末的新工艺,解决β－磷酸三钙湿法制备中长期存在的沉淀物固液难以分离的难题,通过对β－磷酸三钙生物陶瓷的成型条件和烧结条件的研究,建立制备多孔β－磷酸三钙生物陶瓷的适宜工艺,制得适用于修复松质骨缺损的β－磷酸三钙生物陶瓷。     

Fe2O3-CaO-SiO2体系铁磁微晶玻璃的磁性及生物活性

制备了添加少量B₂O₃和P₂O₅后的Fe₂O₃-CaO-SiO₂体系铁磁微晶玻璃,并进行了微观结构分析、XRD分析、磁性检测以及生理模拟液的浸泡实验.实验结果表明,制备的微晶玻璃材料同时具备磁性和生物活性这两种重要性能.不经过核化处理在1 000℃晶化2 h后能够获得较理想的磁铁矿主晶相和硅灰石次晶相均匀致密分布的微观组织,所得微晶玻璃具有最佳的磁性能.铁含量提高能够增加微晶玻璃的磁性,然而会抑制微晶玻璃表面羟基磷灰石的形成,从而降低其生物活性.     

炭粉作造孔剂制备工艺对多孔羟基磷灰石陶瓷性能的影响

以炭粉作造孔剂,制备了孔径在50 nm~1mm的多孔羟基磷灰石陶瓷。运用TG-DTA、SEM等测试手段对产品的微观形貌、力学性能进行了测试分析,并对烧结温度、炭粉加入量等这些影响陶瓷性能的工艺参数进行了研究。     

新型活性生物陶瓷——氟磷灰石

本文作者首次提出了采用溶胶-凝胶(Sol-Gel)技术制备高纯医用氟磷灰石(FAP)粉末,研究了采用粉末冶金技术制取的FAP陶瓷的物理和力学性能,通过X射线衍射分析(XRD)、差热分析(TG/DTA)和扫描电镜(SEM)等分析手段,得出如下重要结论:FAP相结构稳定,在0～1350℃温度范围内无任何相变,使其适合于通过高温烧结制备活性生物陶瓷,在1175℃下烧结90min,可以制得最佳性能的FAP陶瓷材料,其抗弯强度为81MPa,抗压强度为372MPa。     

Mechanical Properties of Polyhydroxyalkanoate Bioceramic Nanocomposites

IntroductionBone substitutes are needed in the repair ofsegmental defects ofbones.A number of polymer/ceramic composites have proved to be suitable forsuch application.Most of the polymers understudy are biopolymers(gelatin and collagen) orsome synthetic polymers (polylactides,polyglycolides,polylactide- co- glycolides,andpolyanhydrides) ,and the commonly used ceramicsare calcium- phos- phate- based bioceramics[15] .　In recent years,a series of polymers,polyhy-droxyalkanoates,have attracted m…     

Fabrication and biological evaluation of polyether ether ketone(PEEK)/bioceramic composites

The repair of vascularized bone defects represents a significantly clinical challenge, and vascular regeneration is one of the necessary factors to promote bone tissue regeneration. To effectively repair large bone defects, new bone tissue must regenerate with a rich vascular network. Therefore, the development of biomaterials that can promote the regeneration of vascularized bone tissue is currently receiving attention from researchers. In this study, Li–Ca–Si bioceramics (LCS) containing Li, Ca, and Si elements was developed, then LCS was compounded with PEEK to prepare PEEK+10% LCS, PEEK+20% LCS, PEEK+30% LCS, and the effect of LCS-PEEK composite biomaterials on the proliferation and angiogenic ability of human umbilical vascular endothelial cells (HUVECs) further explored by Cell Counting Kit-8 (CCK-8), scanning electron microscope (SEM), quantitative real-time PCR (QPCR), Western Blotting and enzyme linked immunosorbent assay (ELISA). The results showed that HUVECs inoculated on 30%LCS ?+ ?PEEK material exhibited the best proliferation ability. And the adhesion ability of endothelial cells on PEEK gradually increased with the increase of LCS contents. Furthermore, the angiogenic ability of HUVECs on LCS-PEEK composites was examined using QPCR and Western blotting, and the results showed that the expression of angiogenic-related genes and proteins of HUVECs on PEEK composites gradually increased with increasing LCS concentration. These results demonstrated that the angiogenic ability of HUVECs was effectively stimulated by LCS-modified PEEK materials. The present results indicate that the PEEK material can be modified with bioceramics to promote angiogenesis, and this study lay the foundation for the subsequent development of scaffolds that promote vascularized bone tissue regeneration.     

生物材料的研究现状与发展

对生物材料的研究现状和发展进行了概述，具体介绍了医用高分子材料、生物陶瓷和医用金属材料的发展现状，综合国内外生物材料的发展现状，对生物材料的未来发展趋势进行了预见。     

可控多孔生物陶瓷制备技术的可控性研究分析

可控多孔生物陶瓷技术的主要优势体现在它的可控性,即制品的孔结构可以根据制备工艺参数来加以控制.为了得到该技术的可控性具体情况,专门对该技术可控性进行了研究分析,选用不同的工艺参数进行研究试验.研究结果表明,该技术只须通过改变有机泡沫微球大小及其含量即可实现多孔生物陶瓷的孔的大小、显气孔率的大小以及孔的连通性等方面的控制,为以后制定具体的孔结构可控的多孔生物陶瓷生产工艺提供依据.     

生物陶瓷多孔结构的分形分析

生物陶瓷的多孔结构与其生物活性密切相关．采用扫描电镜(SEM)观察生物陶瓷的孔壁的显微结构，并采用计算机技术结合分形方法计算了多孔陶瓷内孔的分形维数，结果表明添加微孔造孔剂后，样品的表面分形维数都比未添加的样品大；分形维数数值之间的微小差别与添加的微孔造孔剂有一定的关系。