无溶剂存在下微波照射的苯并三唑N-烷基化反应

报道了无溶剂存在下微波照射的１,２,３－苯并三唑Ｎ－烷基化反应,将１,２,３－苯并三唑和烷基化剂（卤代烷）吸附在固体ＫＦ／Ａｌ２Ｏ３上,用强度适当的微波照射２～３ｍｉｎ,得到相应的Ｎ－烷基化产物．     

N—烷基化氨基酸和氨基酸酯的一步反应

旋光性氨基酸或其酯室温下在NaHTe/EtOH和NaHTe/H_2O体系中与羰基化合物反应,一步得到N-烷基化氨基酸或其酯。具有二级胺基的脯氨酸苄酯亦能高产率生成N-Bzl-L-Pro·OEt。反应条件温和,不发生外消旋化,适用于带有各种基团的氨基酸。     

KF/Al2O3催化1,2,3-苯并三唑N-烷基化

研究了用固体碱ＫＦ／Ａｌ２Ｏ３为缚酸剂,ＤＭＦ为溶剂,以卤代烃为烷基化剂实现１,２,３－苯并三唑Ｎ－烷基化反应．不同的卤代烃,得到不同比例Ｎ１及Ｎ２烷基化产物,烷基化产率在５７％～９５％之间．     

Unexpected and Intriguing Reactivity of Imino Compounds

We have recently discovered a tandem N-alkylation-C-allylation reaction of α-imino esters with organoaluminum reagents and allyltributyltin. In this reaction, iminium salts were readily prepared in situ by the oxidation of aluminum enolates, and the subsequent nucleophilic addition proceeded smoothly to afford N-alkylation-C-allylation products in good yields. During these studies, we focused on the generation of iminium species 2 by oxidizing a readily accessible and stable enol derivative with oxidants. A convenient method has been found for the generation of α-alkoxycarbonyl iminium salts 2 from ketene silyl acetals and the subsequent reaction with nucleophiles.     

4-Formyl-2-（2H-benzotriazol-2-yl）-phenol： an ESIPT chromophore

In the present work, excited state intramolecular proton transfer （ESIPT） emission properties of a new benzotriazole derivative 4-formyl-2-（2H-benzotriazol-2-yl）- phenol （C1） were studied. 4-Formyl-2-（2H-benzotriazol-2- yl）-methoxy-benzene （C2）, 4-formyl-2-（2H-benzotriazol-2- yl）-phenyl acetate （C3） and 4-methyl-2-（2H-benzotriazol- 2-yl）-phenol （C4） were used as the reference molecules. ^1H NMR chemical shift of hydroxy group in C1 was located at more down field than that of C4 or p-hydroxy-benzaldehyde （C5）, respectively. C1 showed two absorption bands in the range of 260-400 nm zones in various solvents, while C2 and C3 exhibited single absorption band. The equal molar mixtures of C2/C5 or C3/C5 showed single absorption band. C2 and C3 displayed single fluorescence emission band in various solvents, while C1 exhibited dual emission bands in some strong polar solvents. Furthermore, the second emission band in these strong polar solvents showed the large Stokes shift. The results show that the second emission band of C1 was produced by ESIPT. C2 and C3 could not undergo ESIPT due to no hydroxy group. The geometry optimization calculation of enol and keto forms in the ground and excited states of C1 provided tough theoretical evidences of ESIPT.     

无机载体试剂作用下苯骈三氮唑的N—烷化

报道了无机载体试剂KOH/Al_2O_3、NaOH/Al_2O_3和K_2CO_3/Al_2O_3在苯骈三氮唑的N-烷化中的应用,详细地研究了在不同的烷化剂和溶剂中,这些无机载体试剂的反应活性。